海洋微藻PUFAs及合成酶基因在肿瘤预防和治疗中的应用  

Marine microalgae PUFAs and synthetase genes application in tumor prevention and treatment

作　　者：马晓磊[1] 张向阳[1] 黄延红[1] 

机构地区：[1]济宁医学院基础学院,山东济宁272067

出　　处：《济宁医学院学报》2013年第4期239-244,共6页Journal of Jining Medical University

摘　　要：多不饱和脂肪酸(PUFAs)对人类的健康至关重要,参与了人体内许多重要的生理反应,尤其是体内n-3PUFAs和n-6PUFAs的相对含量与肿瘤预防和治疗有关。除了在饮食中添加富含n-3PUFAs和n-6PUFAs外,利用PUFAs合成关键酶基因作用于底物在体内合成也是一个重要的途径。研究已获得海洋微藻中多个PUFAs合成关键酶基因,转入肿瘤的宿主细胞后发现该基因在肿瘤细胞内能进行有效异源表达,抑制肿瘤细胞的增殖且导致凋亡,展示了该类基因在肿瘤的基因治疗中具有良好的应用价值。PUFAs was essential for human health, and involved in many important physiological reaction in the human body. Especially the relative content of n-3 PUFAs/n-6 PUFAs was associated with the treatment and prevention of tumor. We can obtain PUFAs from diet which rich in n-3 PUFAs and n-6 PUFAs, and also synthesize PUFAs with the help of PUFAs synthetase gene using fatty acid substances. Study showed that PUFAs synthetase genes of marine microalgae can express effectively in tumor cells, inhibit cell proliferation and lead to apoptosis. It proved that these genes can be applied to tumor cell therapy with good value.

关 键 词：海洋微藻 PUFAS 合成酶基因 基因治疗 

分 类 号：R34[医药卫生—基础医学]