首发Tourette综合征静息态功能磁共振脑比率低频振幅的研究  

Study of fractional amplitude of low frequency fluctuation (fALFF) of resting-state functional magnetic resonance imaging (fMRI) in patients with first-episode Tourette syndrome

作　　者：崔永华[1] 郑毅[1] 金真[2] 贺永[3] 陈旭[1] 

机构地区：[1]首都医科大学附属北京安定医院精神疾病诊断与治疗北京重点实验室,100088 [2]解放军第306医院 [3]北京师范大学认知神经科学与学习国家重点实验室

出　　处：《精神医学杂志》2013年第4期241-245,共5页Journal of Psychiatry

基　　金：国家自然科学基金项目(编号:81071108);首都医学发展基金项目(编号:20093137)

摘　　要：目的 探讨首发Tourette综合征（TS）静息态下功能磁共振（fMRI）脑比率低频振幅（fALFF）的特征.方法 16例TS患儿（研究组）和16例良好匹配的健康受试者（对照组）均接受静息态功能共振（fMRI）扫描.在0.01～0.1 Hz频段内计算fALFF值,两组进行独立样本t检验.结果 研究组患儿基于BOLD信号的fALFF值在如下脑区强于对照组：左侧梭状回（t =4.36,P＜0.05）、右侧壳核（t=3.81,P＜0.05）；研究组患儿基于BOLD信号的fALFF值在如下脑区弱于对照组：左侧额下回三角部（t=-6.13,P＜0.05）、右侧额中回（t=-4.35,P＜0.05）、左侧额上回（t=-4.51,P＜0.05）、左侧枕中回（t=-6.13,P＜0.05）、左侧罗兰迪克岛盖（t=-4.58,P＜0.05）、右侧罗兰迪克岛盖（t=-4.28,P＜0.05）.结论 首发Tourette综合征患儿在一些脑区存在脑功能活动的异常,有助于揭示Tourette综合征的神经生理机制.Objective To explore the characteristics of fractional amplitude of low frequency fluctuation （fALFF） of resting-state functional magnetic resonance imaging （fMRI） in patients with first-episode Tourette syndrome. Methods 16 subjects with first-episode Tourette syndrome and 16 well-matched healthy controls were scaned with resting-state fMRI. Values of fALFF were calculated in the tape limit ranging from 0.01 Hz to O. 1 Hz. Independent-samples T Test was performed between the two groups. Results TS patients showed sig, nificantly higher fALFF than healthy controls in left fusiform gyrus （ t = 4. 36, P 〈 0.05 ）, right putamen （ t --- 3.81, P 〈 0.05 ）. In addition, fALFF in TS patients were significantly lower than those in healthy controls in left pars triangularis gyri frontalis inferioris （t = -6. 13, P 〈0.05）, right midfrontal gyrus （t = -4. 35, P 〈0.05）, left superior frontal gyros （t = -4. 51, P 〈0.05）, left midoccipital gyrus （ t = - 6. 13, P 〈 O. 05 ）, left rolandic operculum （ t = - 4. 58, P 〈 0.05 ） and right rolandic operculum （ t = -4. 28, P 〈 0.05 ）. Conclusion There are abnormal functional activities in some brain areas in patients with TS. Further neuroimaging study may contribute to understand the underlying neurophysiological mechanism of TS.

关 键 词：抽动秽语综合征 磁共振成像 静息态 比率低频振幅 

分 类 号：R749.94[医药卫生—神经病学与精神病学]