D6S1043、D12S391基因座与主动攻击行为的关联研究  

Association study of the polymorphisms of D6S1043,D12S391 loci with the initiative-aggressive behavior

作　　者：杨春[1] 巴华杰[2] 余海鹰[1] 高志勤[1] 赵汉清[1] 过伟[1] 

机构地区：[1]解放军第102医院,江苏常州213003 [2]常州市公安局刑警支队DNA实验室

出　　处：《精神医学杂志》2013年第4期270-273,共4页Journal of Psychiatry

摘　　要：目的 探讨主动攻击行为与D6S1043、D12S391基因座等位基因或基因型的关联情况.方法 采用PCR结合毛细管电泳的方法对江苏地区103例男性主动攻击行为者（研究组）和159例健康男性（对照组）的外周静脉血样进行D6S1043、D12S391基因座的基因型分析,观察两组在D6S1043、D12S391基因座的等位基因及基因型分布差异,以推测与主动攻击行为相关的易感因素和（或）抗性因素.结果 D6S1043、D12S391基因座均符合遗传平衡定律（Hardy-Weinberg定律）（P＞0.05）；在两个群体中D6S1043基因座的基因型12-19的频率分布差异有统计学意义（P =0.000 4,OR=7.511,95％CI：2.084 ～ 27.066）,但等位基因频率分布无差异（P ＞0.05/n）；在D12S391基因座上未发现分布存在显著差异的等位基因及基因型（P ＞0.05/n）.结论 D6S1043基因座的基因型12-19可能为主动攻击行为的易感因素.Objective To investigate the association of the polymorphisms of D6S1043, D12S391 loci with initiative- aggressive behavior. Methods Polymorphisms of D6S1043 and D12S391 loci were genotyped with PCR and capillary electrophoresis method in 103 males with initiative-aggressive behavior and 159 healthy controls in Jiangsu province. Case-control analysis was used to detect the differences of allelic frequency and genotype contribution to find the susceptible factors or resistant factors of initiative-aggressive behavior. Results Genotype distribution of D6S1043 and D12S391 were in Hardy-Weinberg equilibrium （ P 〉 0.05 ） in initiative-aggressive behavior group and control group. Case-control analysis showed significant difference in genotype distribution in genotype 12-19 on D6S1043 （ P = 0. 000 4, OR = 7.511, 95 % CI 2. 084 - 27. 066 ） , but not in allelic frequency （ P 〉 0.05/n ） . There was no significant difference in allelic or genetype distribution on D12S391 locus （ P 〉 0.05/n ） D6S1043 locus might be the susceptible factor of initiative - aggressive behavior. Conclusion Genetype 12-19 on

关 键 词：主动攻击行为 短串联重复序列(STRs) 遗传多态性 病例对照研究 

分 类 号：R749[医药卫生—神经病学与精神病学]