帕利哌酮缓释片与利培酮治疗孤独症的对照研究  

Comparative study of paliperidone ER and risperidone in the treatment of autism

作　　者：周天红[1,2] 孙凌[1,2] 崔炳喜[2] 毛富强[1] 

机构地区：[1]天津医科大学精神医学教研室,天津300070 [2]天津市安定医院,天津300222

出　　处：《天津医科大学学报》2013年第5期399-402,406,共5页Journal of Tianjin Medical University

摘　　要：目的:探讨帕利哌酮缓释片治疗孤独症的疗效及安全性。方法:将63例孤独症患者随机分为两组,分别予以帕利哌酮缓释片(31例)与利培酮(32例)治疗,观察8周。采用临床疗效总评量表严重程度量表(CGI-S),孤独症治疗评估量表(ATEC)评定临床疗效;通过治疗满意度调查问卷(MSQ)调查治疗满意度;采用副反应量表(TESS)评定不良反应。结果:帕利哌酮缓释片组CGI-S评分、ATEC总分及ATEC行为项评分于治疗1周末即较治疗前有所减低(P<0.05);于治疗2周末、4周末及8周末均明显低于治疗前(P<0.01)。ATEC评分中,除了社交项评分在治疗前后无明显改变之外,言语、感知和行为评分均有不同程度地改善,治疗满意度为93.5%。利培酮组CGI-S评分、ATEC总分及ATEC行为项评分于治疗2周末较治疗前有所减低(P<0.05);于治疗4周末及8周末均明显低于治疗前(P<0.01),治疗满意度为71.9%。两组比较,治疗第1周末、第2周末和第4周末,帕利哌酮缓释片组CGI-S评分、ATEC总分及ATEC行为项评分低于利培酮组,差异有统计学意义(P<0.05);治疗第8周末评分差异无显著性(P>0.05)。两组不良反应均较轻微,多可自行缓解,帕利哌酮组患者家属治疗满意度高于利培酮组(P<0.05)。结论:帕利哌酮缓释片与利培酮疗效及安全性相当,均可有效控制孤独症易怒情绪,但帕利哌酮缓释片比利培酮起效快,服药简便,依从性好,值得推广应用。Objective： To evaluate the effect and safety of paliperidone ER in the treatment of autism. Methods： Sixty-three cases of autism were randomly divided into two groups which were respectively treated with paliperidone ER （n=31 ） and risperidone tablets （n=32） for 8 weeks. Clinical Global Impression-Severity Scale （CGI-S）, Autism Treatment Assessment Scale （ATEC） were adopted to assess clin ical effect; Treatment satisfaction of patient＇s relatives was measured by Medication Satisfaction Questionnaire （MSQ）; adverse reactions were evaluated with Treatment Emergent Symptom Scale （TESS）. Results： Compared with those before treatment, scores of CGI-S, ATEC at the end of 1 st week in palipericlone ER group were lower （P〈0.05）, and at the end of 2nd, 4th and 8th week the scores were significantly lower （P〈0.01）. In addition, no significant score change before and after treatment was found in social factors in ATEC scale. Speech per- ception and behavior scores were increased to varying degrees. The treatment satisfaction was 93.5% among relatives of patients. Compared with those before treatment, scores of CGI-S, ATEC at the end of 2nd week in risperidone group were lower （/）〈0.05）, and at the end of 4th and 8th week the scores were significantly lower （P〈0.01）. The treatment satisfaction was 71.9% among relatives of patients. The CGI-S score, ATEC total score and behavior items score of ATEC in paliperidone ER group were lower than those in risperidoue group, and the difference was statistically significant （/）〈0.05）; No statistically significant difference was found in the treatment at the end of 4th week and 8th week（P〉0.05 ）. Adverse reactions were all mild, and most can be alleviated by itself, and the satisfaction treatment paliperidone ER was significantly higher than that in risperidone group （P〈0.01）. Conclusion： Paliperidone El：{ can effectively control the symptoms of autism irritability. Paliperidone ER and risperidone were com

关 键 词：帕利哌酮缓释片 利培酮 孤独症 疗效 安全性 

分 类 号：R749[医药卫生—神经病学与精神病学]