吡拉西坦对精神分裂症认知功能障碍的影响  

Effects of Piracetam on cognitive dysfunction in schizophrenia

作　　者：陶建青[1] 赵玮琳[1] 尹雪冰[1] 曾强[1] 莫显祥[1] 黄瑞荣[1] 

机构地区：[1]广西壮族自治区人民医院心理康复中心精神科,广西南宁530021

出　　处：《中国医药导报》2013年第27期68-70,共3页China Medical Herald

基　　金：广西壮族自治区卫生厅科研课题(合同号:Z2007162)

摘　　要：目的探讨吡拉西坦对精神分裂症患者认知功能障碍的影响。方法将服用第一代抗精神病药物有认知功能障碍的精神分裂症患者80例随机分为研究组与对照组,各40例,研究组联合吡拉西坦治疗,对照组单独使用抗精神病药物治疗。分别于治疗前、治疗后12周进行阳性与阴性症状量表(PANSS)、数字广度测验(DST)、语词流畅性测验(VFT)、钉板实验(GPT)、连线试验A(TMT-A)及威斯康星卡片分类测验(WCST)评估。结果研究组治疗后PANSS总分为(49.8±8.2)分,对照组为(49.4±13.3)分,均低于治疗前(P<0.05)。研究组治疗后DST为(9.22±1.94)个,VFT为(7.89±4.21)个,正确应答数为(39.49±9.83)张,均比治疗前提高(P<0.05或P<0.01),并且高于治疗后的对照组(P<0.05或P<0.01);持续性错误数为(20.94±7.73)张,较治疗前下降(P<0.05),且低于同期对照组(P<0.05)。GPT、TMT-A以及WCST的总应答数、完成分类数治疗前后比较以及两组间同期比较差异均无统计学意义(P>0.05)。结论吡拉西坦可部分改善精神分裂症患者的认知功能。Objective To explore the effects of Piracetam on the cognitive disorder in patients with schizophrenia. Methods 80 cases of cognitive dysfunction in schizophrenia patients who took the first-generation antipsychotic drugs were randomly divided into study group and control group, with 40 cases in each group, the study group was combined with Piracetam, the control group was received antipsychotic treatment alone. Positive and negative syndrome scale （PANSS）, digit span test （DST）, verbal fluency test （VFT）, grooved pegboard test （GPT）, trail making test-A （TMT-A） and wisconsin card sorting test （WCST） were assessment before and after treatment respectively. Results Total score of PANSS in study group after treatment was （49.8±8.2） points, the control group was （49.4±13.3） points, which were all lower than before treatment （P 〈 0.05）. DST of the study group after treatment was （9.22±1.94） pieces, VFT was （7.89± 4.21）, Rc was （39.49±9.83） pieces, higher than before treatment （P 〈 0.05 or P 〈 0.01）, and higher than after treat- ment in the control group （P 〈 0.05 or P 〈 0.01） respectively; Rpe was （20.94±7.73） pieces, compared with before treatment there was significant difference （P 〈 0.05）, and lower than the same period in the control group （P 〈 0.05）. GPT, TMT-A and WCST （Ra）, number of categories completed （Cc） had no statistical significance between the two groups before and after treatment and the comparison at the same time between the two groups （P 〉 0.05）. Conclusion Piracetam can improve cognitive function of schizophrenic patients.

关 键 词：精神分裂症 认知功能障碍 吡拉西坦 

分 类 号：R749.3[医药卫生—神经病学与精神病学]