高危人群补硒预防肝癌的作用  

The prevention of primary liver cancer by selenium in high risk populations

作　　者：李文广[1] 诸亚君[2] 颜晓文[3] 张启南[1] 李学汤[2] 倪正平[1] 沈卓才 姚红玉[1] 朱健[1] 

机构地区：[1]江苏省启东肝癌防治研究所,226200 [2]中国医学科学院肿瘤研究所 [3]北京希力药业集团公司

出　　处：《中华预防医学杂志》2000年第6期336-338,共3页Chinese Journal of Preventive Medicine

基　　金：国家"九五"攻关项目资助 !(96 90 6 0 1 0 6 )

摘　　要：目的　研究补硒对预防原发性肝癌的作用。方法　检测男性 2 0～ 6 5岁 180 0 0人 ,检出HBsAg(+ )、AFP(- )、肝功能 (ALT)基本正常的患者 2 0 6 5例 ,按地区随机分为补硒组 1112例及对照组95 3例。补硒组每人每天服亚硒酸钠 1片 0 5mg,对照组服安慰剂 1片。前瞻观察 3年。结果　补硒组血硒显著升高 ,相应谷胱甘肽过氧化酶随之升高 ;相反外周血淋巴细胞微核检出率补硒组低于对照组。肝癌发病率补硒组 3 0 5 7 5 5 /10万 (34/1112 ) ,对照组 5 981 11/10万 (5 7/95 3)。结论　补硒方法简单 ,易以推广。在肝癌高发区高危人群中 ,尤其是低硒地区 。Objective To study the preventive effects of selenium on primary liver cancer. Methods After screening of blood samples in 18 000 males from 20 to 65 years old in Qidong, Jiangsu province (a high risk area for liver cancer), 2 065 cases of HBsAg positive, AFP negative and normal liver function (normal ALT values) were found. The subjects were randomly divided into two groups, based on their residence areas; 1 112 subjects (experimental group) received one tablet of sodium selenite (0 5 mg Se) every day and 953 subjects (control group) received one placebo tablet every day. Results During three years of intervention and follow up, the blood selenium concentration and glutathione peroxidase activity of the subjects in the experimental group were increased and had significant difference as compared with those of the control group ( P< 0 01). At the same time, the prevalence rate of micronucleus cells in peripheral blood lymphocytes in the experimental group was significantly lower than that of the control group ( P< 0 01), and the incidence of new liver cancer in the experimental group (3 057 55/ 10 6, 34 cases out of 1 112 subjects) was significantly lower than the control group (5 981 11/ 10 6; 57 cases out of 953 subjects) ( P< 0 01). Conclusion The results confirms that selenium supplementation in general populations lived in high risk is effective in the prevention of liver cancer and the using of selenium tablets is simple and feasible.

关 键 词：补硒 亚硒酸钠 肝肿瘤 预防 

分 类 号：R735.7[医药卫生—肿瘤]