饮水中微囊藻毒素对人群健康影响的横断面研究  

A cross sectional study on the effects of microcystin in drinking water to the health of human beings

作　　者：连民[1] 刘颖[2] 俞顺章[1] 陈传炜[1] 周学富[3] 周余春 丁保国[3] 王如鸿 

机构地区：[1]上海医科大学预防医学研究所环境医学与分子生物研究室,200032 [2]上海医科大学,200032 [3]江苏省泰兴市卫生防疫站

出　　处：《中华流行病学杂志》2000年第6期437-440,共4页Chinese Journal of Epidemiology

基　　金：国家自然科学基金资助项目!(39730380 )

摘　　要：目的　初步了解饮水中微囊藻毒素 (MC)对人体健康的影响。方法　采用横断面研究方法 ,在泰兴肝癌高发区两个不同饮水类型的学校里分别随机抽取 111名和 92名学生 ,对其进行调查 ,并采集静脉血 ,检测血清中乙型肝炎病毒 (HBV)感染标志物及血清丙氨酸氨基转移酶 (ALT)、γ 谷氨酰转移酶 (γ GT)、碱性磷酸酶 (ALP)水平。按照HBV感染进行分层 ,比较两组人群血清三种酶学水平的差异。结果　两组人群三种酶学指标差异存在显著性 (P <0 .0 1) ,暴露组高于对照组。结论　长期饮用有微囊藻毒素污染的水可能对肝脏有损害作用 ,引起血清中某些肝脏酶学指标的升高。Objective To understand the effects of microcystin(MC) in drinking water on health of human beings. Methods In Taixing, a cross sectional study was conducted in two middle schools with different types of drinking water, from which 111 and 92 students were randomly selected and investigated. Blood samples from all individuals were collected and tested for serum HBsAg, HBeAg, anti HBe, anti HBs, anti HBc with enzyme linked immunoabsorbent assay and for serum alanine aminotransferase(ALT),γ glutamyltransferase(γ GT) and alkaline phosphatase(ALP) contents by colorimetry. These levels of enzymes in sera were compared after the students were stratified according to the status of HBV infection. Result With the exclusion of the effect of HBV infection, three enzymes levels in sera between two groups of students showed significant differences ( P < 0.01 ), much higher in exposure group than those in control group. Conclusion MC was possibly harmful to human beings in drinking water and induced the contents of some enzymes from the liver of human beings to increase in sera.

关 键 词：饮水 微囊藻毒素 流行病学 横断面研究 肝癌 

分 类 号：R735.7[医药卫生—肿瘤] R123.5[医药卫生—临床医学]