益生菌对肠黏膜屏障的作用机制  

The mechanism of action of probiotics on intestinal mucosal barrier

作　　者：林楠(综述)[1] 孙梅(审校)[1] 

机构地区：[1]中国医科大学附属盛京医院小儿消化科,沈阳110004

出　　处：《国际儿科学杂志》2013年第5期493-496,共4页International Journal of Pediatrics

基　　金：基金项目：高等学校博士学科点专项科研基金资助项目（20092104110010）;辽宁省教育厅科技计划资助项目（L2010624）;辽宁省博士启动基金资助项目（20101147）;沈阳市科学技术计划资助项目（F10-205-1-45）

摘　　要：肠黏膜屏障是指正常肠道具有的将肠腔内物质与机体内环境隔离，防御外来抗原及致病性病原体侵入黏膜下层组织的功能，维持机体内环境的相对稳定和机体的正常生命活动。肠黏膜屏障功能的损伤与多种胃肠道疾病的发生密切相关。益生菌是指摄取后在肠道达到一定数量能够对宿主起有益作用的活微生物，它能够改善或预防多种胃肠道疾病，其主要机制为益生菌能够通过多种途径维持肠黏膜屏障功能。该文就益生菌对肠黏膜屏障功能的具体作用机制作一综述。Intestinal mucosal barrier has the function to isolate intestinal contents and internal environ- ment,prevent foreign antigens and pathogens invading to lamina propria mucosae and can maintain organic ho- meostasis and normal activities. Impairment of the intestinal barrier is a key event in various gastrointestinal dis- eases. Probiotics are live microorganisms which ingested and reach the intestines in sufficient numbers to confer benefit to the host. It can improve or prevent many gastrointestinal diseases. The main reason is probiotics can maintain intestinal barrier function in various paths. This paper reviews its mechanisms of action.

关 键 词：益生菌 肠黏膜 紧密连接 黏蛋白类 免疫 防御素类 细菌黏附 

分 类 号：R574[医药卫生—消化系统]