强化长链不饱和脂肪酸配方奶应用于早产儿营养价值的临床研究  

Clinical Study of Nutritive Value on Premature Infant Fed Long chain Polyunsaturated Fatty Acids Enrichment Formula

作　　者：李在玲[1] 赵凤临[1] 罗凤珍[1] 赵瑞玲[1] 王丽德[2] 张京平 卜学芳 何德阳莉 米久保明得 桑田有 

机构地区：[1]北京大学第三医院儿科,100083 [2]北京大学医学部康力天然保健品研究所 [3]日本明治乳业株式会社营养科学研究所

出　　处：《中华围产医学杂志》2000年第4期231-234,共4页Chinese Journal of Perinatal Medicine

摘　　要：目的　对强化长链不饱和脂肪酸配方奶应用于早产儿的营养价值进行临床研究。　方法　将早产儿随机分为试验组 (强化长链不饱和脂肪酸配方奶组 )和对照组 (普通早产儿配方奶组 )各30例。比较两组生长发育和有关实验室指标 ,观察时间为 4周。　结果　试验组血清脂肪酸 2 0 :5 n- 3和2 2 :5 n- 3含量及 n- 3系不饱和脂肪酸总含量高于对照组 [(0 .37± 0 .11) m ol%与 (0 .19± 0 .11) mol% ;(0 .2 7± 0 .17) mol%与 (0 .15± 0 .0 7) m ol% ;(2 .2 0± 0 .73 ) mol%与 (1.6 8± 0 .5 1) m ol% ](P<0 .0 1)。n- 6 / n- 3比值低于对照组 ,差异有非常显著性 (4 .19± 0 .97与 5 .47± 1.2 4) (P<0 .0 1)。试验组与对照组相比 ,体重、身长、头围、胸围的增长及其他各项实验室生化指标的差异均不显著 (P>0 .0 5 )。　结论试验组配方奶的脂肪酸组成接近于人乳 ,适用于早产儿 。Objective To evaluate the nutrient effect of premature infants fed long chain polyunsaturated fatty acids (LCP)enrichment formula. Methods Premature infants were randomly assigned into two groups: experimental group(group A,LCP enrichment formula,n=30)and control group(group B,other formula for premature infant,n=30).Clinical symptoms had been observed continually for 4 weeks. The laboratory data were monitored at the Beginning and the end of the study in both groups. Results The concentration of fatty acid compositions of plasma :20:5 n 3, 22:5 n 3 and total(n 3)LCP were significant higher in group A(0.37±0.11) mol% ,(0.27±0.17) mol%,(2.20±0.73) mol% than that in group B(0.19±0.11) mol%,(0.15±0.07) mol%,(1.68±0.51) mol%), P <0.01. The ratio of n 6/n 3 in group A was significant lower than that in group B(4.19±0.97 vs 5.47±1.24), P <0.01.The weight, height, head circumference, thorax circumference gain in group A were as much as that in group B ( P >0.05). No significant difference of laboratory data were found between the two groups ( P >0.05). Conclusion LCP enrichment formula is suitable to premature infants. Its lipid composition is more close to that of breast milk and benefit to the brain and retina development of premature infants.

关 键 词：婴儿 早产 食品 配方 脂肪酸类 不饱和 营养价值 

分 类 号：R722.6[医药卫生—儿科] R153.2[医药卫生—临床医学]