凝血因子ⅦR353Q基因多态性与中国汉族儿童脑性瘫痪的相关性研究  

Relationship between Gene Polymorphism of Factor Ⅶ R353Q and Cerebral Palsy for Han Chinese Children

作　　者：李晓捷[1,2] 徐磊[1,2] 康贝贝[1] 

机构地区：[1]佳木斯大学康复医学院,黑龙江佳木斯市154002 [2]佳木斯大学儿童神经康复实验室,黑龙江佳木斯市154002

出　　处：《中国康复理论与实践》2013年第9期878-880,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：黑龙江省研究生创新科研资金项目(No.YJSCX2012-358HLJ);佳木斯大学科学技术面上项目(No.L2012-032)

摘　　要：目的探讨凝血因子ⅦR353Q基因多态性与中国汉族儿童脑瘫的关系。方法应用聚合酶链反应与限制性片断长度多态性分析方法对160例脑瘫患儿和137名正常儿童的凝血因子ⅦR353Q基因型和等位基因进行测定。结果脑瘫组和对照组人群凝血因子ⅦR353Q基因型分布符合Hardy-weinberg平衡定律(P>0.05),两组凝血因子ⅦR353Q基因型(P=0.436)和等位基因分布无显著性差异(P=0.182)。结论凝血因子ⅦR353Q基因多态性不是中国汉族儿童脑瘫发病的遗传易感因子。Objective To investigate the relationship between gene polymorphism of factor VII R353Q （FVII R353Q） and cerebral pal- sy for Han Chinese children. Methods Polymerase chain reaction-restricted fragment length polymorphism were used to determine geno- type and allele ofR353Q gene in 160 children with cerebral palsy and 137 normal children. Results The genotype of FVII R353Q is close to Hardy-Weinberg equilibrium in both CP group and control group （P〉0.05）. There was not significant difference in the distribution of the al- lelic frequency and genotype of FVII R353Q between the both groups （P=0.436, P=0.182, respectively）. Conclusion The gene polymor- phism ofFVII R353Q is not significantly related with cerebral palsy for Han Chinese children.

关 键 词：脑性瘫痪 汉族 凝血因子VIIR353Q 基因多态性 

分 类 号：R742.3[医药卫生—神经病学与精神病学]