阿尔茨海默病与血管性痴呆定量脑电图波频差异研究  

QEEG Wave Frequency Differences between Alzheimer's Disease and Vascular Dementia

作　　者：徐清[1] 徐文炜[1] 张玉琦[1] 堵强 陆春英[1] 蒋幸衍[1] 吴越[1] 朱建中[1] 李鹏鹏[1] 

机构地区：[1]江苏省无锡市精神卫生中心老年精神科,214151

出　　处：《中国全科医学》2013年第22期2584-2588,共5页Chinese General Practice

基　　金：无锡市科技指导性计划项目(CSZOON1235)

摘　　要：目的探讨阿尔茨海默病(AD)与血管性痴呆(VD)定量脑电图(EEG)波频差异,慢、快波比例与AD、VD认知能力的关系。方法将30例AD患者、30例VD患者与30例正常老年人行EEG功率谱分析及视觉EEG评分。功率谱按频率分:δ(0.8～4.0 Hz)、θ(4.0～7.8 Hz)、α(7.8～12.8 Hz)、β(13.0～20.0 Hz),以(δ+θ)/(α+β)值作为观察评估指标进行比较。对3组全脑、额叶、颞叶、顶叶、枕叶、中央、左额叶、左颞叶、左顶叶、左枕叶、左中央、右额叶、右颞叶、右顶叶、右枕叶及右中央的(δ+θ)/(α+β)值及视觉EEG评分进行比较。将AD、VD患者的简易智力状态检查量表(MMSE)评分和(δ+θ)/(α+β)值进行相关分析。结果 AD组在全脑、额叶、颞叶、顶叶、枕叶、中央、左额叶、左颞叶、左顶叶、左枕叶、左中央、右额叶、右颞叶、右顶叶、右枕叶、右中央的(δ+θ)/(α+β)值及视觉EEG评分高于对照组,差异有统计学意义(P<0.05)。VD组除右颞叶及右中央,其余各观察区域的(δ+θ)/(α+β)值高于对照组,差异有统计学意义(P<0.05)。VD组的视觉EEG评分与对照组比较差异无统计学意义(P>0.05)。AD组与VD组各观察区域(δ+θ)/(α+β)值间差异无统计学意义(P>0.05)。VD组除枕叶,其余观察区域左额叶、左颞叶、左顶叶及左中央(δ+θ)/(α+β)值高于右侧对称部位,差异有统计学意义(P<0.05)。AD组、对照组各观察区域的左右对称部位(δ+θ)/(α+β)值间差异无统计学意义(P>0.05)。AD、VD组MMSE评分、视觉EEG评分与各区域(δ+θ)/(α+β)值呈负相关(P<0.05)。结论定量脑电图作为一种客观、量化的脑功能检测手段,有助于AD、VD早期诊断、鉴别诊断及病情监测,对AD、VD患者认知能力评估有重要价值。Objective To explore the differences of QEEG wave frequency between Alzheimer＇s disease（AD） and vascular dementia（VD）,and the relation between slow/ fast wave ratio and cognitive function in patients with AD and VD.Methods 30 patients with AD,30 patients with VD,and 30 healthy aged people（control group） were measured with QEEG and Visual EEG.Power spectrum was classified into the delta waves（0.8-4.0 Hz）,theta waves（4.0-7.8 Hz）,alpha waves（7.8-12.8 Hz）,and beta waves（13.0-20.0 Hz）.Values of（δ ＋ θ）/（α ＋ β） were compared as an evaluation index.The（δ ＋ θ）/（α ＋ β） power ratios and Visual EEG scores of the whole brain,frontal lobe,temporal lobe,parietal lobe,occipital lobe,central lobe,left frontal lobe,left temporal lobe,left parietal lobe,left occipital lobe,left central lobe,right frontal lobe,right temporal lobe,right parietal lobe,right occipital lobe and right central lobe were compared,respectively.Pearson correlation analysis was used to explore the relationship between the mini-mental state evaluation（MMSE） score and the（δ ＋ θ）/（α ＋ β） value of the AD and VD patients.Results The AD group had higher（δ ＋ θ）/（α ＋ β） value and visual EEG score in the whole brain,the frontal lobe,temporal lobe,parietal lobe,occipital lobe,central lobe,left frontal lobe,left temporal lobe,left parietal lobe,left occipital lobe,left central lobe,right frontal lobe,right temporal lobe,right parietal lobe,right occipital lobe,and right central lobe than the control group（P 0.05）.The VD group had higher（δ ＋ θ）/（α ＋ β） value of the above regions except the right temporal lobe and right central lobe than the control group（P 0.05）.However,no significant difference was observed in visual EEG score between the VD group and the control group（P 0.05）.No significant difference was observed in（δ ＋ θ）/（α ＋ β） value of all the regions between AD and VD group（P 0.05）.The（δ ＋ θ）/（α ＋ β） val

关 键 词：阿尔茨海默病 痴呆 血管性 定量脑电图 认知功能 

分 类 号：R749.16[医药卫生—神经病学与精神病学]