非小细胞肺癌患者血清粒细胞集落刺激因子水平测定及意义研究  

Clinical Significance of Serum Granulocyte Colony-stimulating Factor Level in Patients with Non-small-cell Lung Carcinoma

作　　者：马若亭[1] 胡春宏[1] 杨敏[1] 

机构地区：[1]中南大学湘雅三医院老年科,湖南省长沙市410013

出　　处：《中国全科医学》2013年第24期2816-2818,共3页Chinese General Practice

摘　　要：目的测定血清粒细胞集落刺激因子(G-CSF)在非小细胞肺癌(NSCLC)患者血清中的水平,分析其临床意义。方法收集经病理证实的初诊初治NSCLC患者50例,应用酶联免疫双抗体夹心法检测患者手术前后血清G-CSF水平,并分析手术前后血清G-CSF水平变化;血清G-CSF与NSCLC病理特征间的关系。结果术后血清G-CSF水平低于术前(P<0.01);术后白细胞计数及中性粒细胞计数均低于术前(P<0.05)。年龄<60岁的NSCLC患者血清G-CSF水平≥60岁者(P<0.05);大细胞癌患者的血清G-CSF水平较鳞癌和腺癌患者均高,鳞癌患者较腺癌患者高,差异均有统计学意义(P<0.05);组织学分级Ⅲ级患者的血清G-CSF水平较Ⅰ级和Ⅱ级均高,Ⅱ级较Ⅰ级高,差异均有统计学意义(P<0.01);血清G-CSF水平与肿瘤大小无相关性(r=0.174,P>0.05);有淋巴结转移者的血清G-CSF水平高于无淋巴结转移者(P<0.05)。结论 NSCLC患者术后血清G-CSF水平较术前低,血清G-CSF水平与NSCLC患者的年龄、肿瘤组织学类型、分化程度、有无淋巴结转移有关,可作为一种新型肿瘤标记物应用于临床,作为诊断、监测病情、判断疗效的指标。Objective To determine the serum granulocyte colony - stimulating factor （ G - CSF） level in patients with non -small -cell lung carcinoma （NSCLC） in order to analyze its clinical significance. Methods 50 pathologically con- firmed and newly diagnosed NSCLC patients were analyzed. The concentrations of serum G - CSF before and after operation were measured by ELISA and compared. Results Postoperative G - CSF level was significantly lower than preoperative level （ P 〈 0. 01 ） . Postoperative white blood cell counting and granuloeyte counting were significantly lower than preoperative levels （ P 〈 0.05 ） . NSCLC patients under 60 years old had significantly higher G - CSF level than patients over 60 years old （ P 〈 0. 05 ）. The G - CSF level of large cell lung carcinoma patients was significantly higher than the squamous cell carcinoma and adenocarci- noma patients, while the G - CSF level of squamous cell carcinoma patients was significantly higher than adenocarcinoma patients （ P 〈 0. 05 ） . The G - CSF level of degree m patients was significantly higher than degree I and degree II patients, while de- gree II patients were also significantly higher than degree I patients （ P 〈 0. 01 ） . The G - CSF level was not correlated with the size of tumor （r= 0. 174, P 〉 0. 05 ） . Patients with lymph node metastasis had significantly higher G - CSF level compared with patients without lymph node metastasis （ P 〈 0. 05 ） . Conclusion Serum level of G - CSF in post - operation patients with NSCLC is lower than that in pre - operation NSCLC patients. Serum G - CSF level of the patients with NSCLC is closely related with the patient age, tumor histological type, differentiation and lymph node metastasis. G - CSF may be used as a new tumor marker for clinical application. It may be used as an indicator for diagnosis, monitoring disease and judging the curative effect.

关 键 词：癌 非小细胞肺 粒细胞集落刺激因子 肿瘤标记  生物学 

分 类 号：R734.2[医药卫生—肿瘤]