血小板计数增多与喉鳞癌预后的关系研究  

Relationship between High Peripheral Platelet Count and Poor Prognosis of Laryngeal Squamous Cell Carcinoma

作　　者：祝佼[1] 骆文龙[1] 

机构地区：[1]重庆医科大学附属第二医院耳鼻咽喉头颈外科,重庆市400010

出　　处：《中国全科医学》2013年第24期2819-2822,共4页Chinese General Practice

摘　　要：目的探讨血小板计数增多与喉鳞癌预后之间的关系。方法对169例初发喉鳞癌患者的血小板计数、病理分化程度、临床分期(T分期)、有无淋巴结转移(N分期)、有无远处转移(M分期)和生存时间进行比较分析。结果 (1)喉鳞癌患者的血小板计数〔(195.4±92.0)×109/L〕高于健康者〔(171.4±44.6)×109/L〕,差异有统计学意义(t=3.001,P=0.003)。(2)169例喉鳞癌患者中血小板计数增多者共24例(14.2%)。随着病理分化程度分级升高,血小板计数增多者增多;T3+4血小板计数增多者较T1+2组增多;N+组血小板计数增多者较N0组增多;M0组血小板计数增多者较M+组增多,差异均有统计学意义(P<0.05)。(3)Log-rank检验显示,不同血小板计数、TNM分期喉鳞癌患者3年生存率比较,差异均有统计学意义(P<0.05)。(4)Cox比例风险模型分析影响喉鳞癌患者生存预后的因素,结果显示,血小板计数、病理分化程度及TNM分期均进入风险模型。结论血小板计数增多与喉鳞癌的预后不良有关。Objective To investigate the relationship of high peripheral blood platelet count and poor prognosis with laryngeal squamous cell carcinoma. Methods The platelet count, pathological classification, TNM staging and survival time of 169 patients with laryngeal squamous carcinoma were analyzed. Results （ 1 ） Platelet count of patients with laryngeal squamous cell carcinoma [ （ 195.4 ± 92. 0） × 10^9/L]. was significantly higher than that of healthy cases [ （ 171.4 ±44. 6） × 10^9/L] （t =3. 001, P = 0. 003 ） . （2） There is a close correlation between high platelet counts and histological classification （P = 0. 0002） and T （P =0. 003） N （P =0. 022） M （P 〈0. 001） stage. 24 patients had increased platelet count （14. 2% ） . （3） The 3 - year survival rate of normal platelet count patients （20. 8% ） was significantly higher than that of high platelet count pa- tients （71.0%） . （4） Besides TNM stage and pathological differentiation degree （P 〈 0. 05 ）, high platelet counts （P = 0. 013 ） was an independent risk factor for the prognosis of laryngeal squamous cell carcinoma. Conclusion High platelet count is correlated with poor prognosis of laryngeal squamous cell carcinoma.

关 键 词：血小板计数 喉肿瘤 癌 鳞状细胞 预后 

分 类 号：R739.65[医药卫生—肿瘤]