Alzheimer病和血管性痴呆患者APOE及LRP基因多态性与认知及精神行为症状相关性研究  

APOE and LRP gene polymorphisms are associated with clinical symptoms in patients with dementia

作　　者：吕泽平 胡才友[2] 周琴[2] 杨泽[3] 梁庆华[2] 黄春丽[2] 庞国防[2] 杨秀塔[2] 

机构地区：[1]国家康复辅具研究中心附属康复医院神经内科,100176 [2]广西壮族自治区江滨医院神经内科,530021 [3]卫生部北京老年医学研究所遗传室,100730

出　　处：《中国神经免疫学和神经病学杂志》2013年第5期331-334,共4页Chinese Journal of Neuroimmunology and Neurology

基　　金：广西科学研究与技术开发计划项目(桂科攻0719006-2-3;1355005-6-2);广西医药卫生重点课题(重200953)

摘　　要：目的探讨Alzheimer病(AD)和血管性痴呆(VD)患者APOE及LRP基因多态性与认知及精神行为症状(BPSD)的相关性。方法收集AD患者79例、VD患者85例和健康对照者(对照组)156名,采用简易精神状态检查量表(MMSE)评定认知功能;采用简明精神病量表和汉密尔顿抑郁(HAMD)、焦虑量表(HAMA)评定BPSD。采用PCR-RFLP进行APOEε、LRP基因分型。结果 (1)AD组(17.7%)及VD组(20.5%)APOEε4等位基因频率均高于对照组(5.7%,均P<0.01)。(2)AD组和VD组APOEε4携带者MMSE得分均低于同组APOEε4非携带者〔AD组(13.84±2.32)分vs.(14.78±2.54)分,P<0.01;VD组(15.53±1.87)分vs.(18.45±2.23)分,P<0.01〕。(3)AD组患者APOEε4携带者BPSD比例明显高于APOEε4非携带者(55.56%vs.52.83%,P=0.039)。结论 APOEε4可能是AD、VD患者认知障碍的共同危险因素。APOEε4可能是AD的BPSD危险因素。Objective To explore the association among APOE, LRP gene polymorphisms and dementia. Cognitive function, behavioral and psychological symptoms of dementia （BPSD） in patients with Alzheimer＇ s disease （AD） and vascular dementia （VD） were studied. Methods Seventy-nine patients with AD, 85 patients with VD, and 156 subjects without dementia as control group were included in the study. All the subjects were recruited from outpatients and inpatients. The cognitive function was assessed by the Mini-Mental State Examination （MMSE）. BPSD were assessed by the Brief Psychiatric Rating Scale （BPRS）, the Hamilton Depression Rating Scale （HAM-D）, and Hamilton Anxiety Rating Scale （HAM-A）. The genotyping was tested by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） methods. Results （1） APOEε4 allele frequencies were higher in both AD and VD group compared with the control group （AD： 17.7% vs. 5.7%, P〈0. 01; VD： 20.5% vs. 5.7%, P〈0. 01）. （2） In both AD and VD group, APOEt4 carriers had a lower MMSE score compared with APOEt4 non-carriers （AD： 13.84±2.32 vs. 14.78±2.54, P〈0.01; VD： 15. 53±1.87 vs. 18.45±2.23, P〈0.01）. （3） In the AD group, the proportion of patients who had BPSD were higher in the APOEt4 carriers group compared with the APOEε4 non-carriers group （55. 560/00 vs. 52.83%, P= 0. 039）. Conclusions ApoEε4 is a common risk factor for cognitive impairment in the patients with AD and VD. ApoEε4 is a risk factor for BPSD in patients with AD.

关 键 词：阿尔茨海默病 血管性痴呆 APOE基因 LRP基因 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R446[医药卫生—临床医学]