COPD患者血清IL-27水平及其与FEV_1功能关系研究  

Association between serum IL-27 level and function of FEV_1 in COPD patients

作　　者：曹梅[1] 许浦生[1] 萧鲲[1] 叶凯[1] 陈飞鹏[1] 

机构地区：[1]广州医学院第二附属医院呼吸内科,广东广州510260

出　　处：《临床肺科杂志》2013年第11期1963-1965,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的比较不同分期慢性阻塞性肺部疾病患者及正常人血清中IL-27、s-ICAM-1水平的差异;探讨IL-27、s-ICAM-1与第1秒用力呼气容积占预计值百分比之间相关关系。方法采用ELISA法检测35例COPD患者血清IL-27、s-ICAM-1水平,测定患者FEV1%预计值水平,与30例健康对照比较,并探讨指标间相关关系。结果血清IL-27水平急性加重期>稳定期>对照组,P均小于0.001,血清IL-27水平与FEV1%预计值相关系数r=-0.65,P<0.05;s-ICAM-1水平急性加重期>稳定期>对照组,P均小于0.05,s-ICAM-1水平与FEV1%预计值相关系数r=-0.857,P<0.05。结论 IL-27,s-ICAM-1在COPD患者中高表达,其水平随着肺功能下降而升高,机理可能是这两个炎性因子参与了COPD气道炎症反应。Objective To compare the differences of serum interleukin-27 （IL-27） and s-ICAM-1 in COPD patients at different severity stages and healthy controls, and to explore the relationship between the levels of serum IL-27 and s-ICAM-1 and forced expiratory volume at the first second （ FEV1% pred）. Methods The study selected 35 COPD patients as the study group and 30 healthy people as the control group. Their serum levels of IL-27 and s-ICAM-1 were detected by ELISA. Results The serum level of IL-27 was the highest in the acute-outbreak group, followed by the stable group and the control group （ P 〈 0. 001 ）. IL-27 and s-ICAM-1 were negatively correlated with FEV1% pred respectively （ r = - 0. 857, P 〈 0. 05 ）. Conclusion Serum IL-27 and s-ICAM-1 may act powerfully in the COPD via inflammatory response.

关 键 词：IL-27 s-ICAM-1 COPD FEV1%预计值 

分 类 号：R563.9[医药卫生—呼吸系统]