目的:研究白细胞介素27(interleukin-27,IL-27)对辅助性T细胞1(helper T cell 1,Th1)分化及急性肺损伤的影响与作用机制。方法:通过盲肠结扎穿刺(cecal ligation and puncture,CLP)构建脓毒症急性肺损伤小鼠模型,苏木精-伊红(hematoxyli...
supported by the funds from National Natural Science Foundation of China(No.82304506,No.82373887,No.82373725);the China Postdoctoral Science Foundation(2022M723513,China).
Purinergic signaling plays a causal role in the modulation of immune inflammatory response in the course of psoriasis,but its regulatory mechanism remains unclear.As a member of purinoceptors,P2Y_(6)R mainly distribut...