HBV X蛋白调控微小RNA致肝细胞癌发生机制的进展  

Advances in microRNA regulated hepatitis B virus X protein in the pathogenesis of hepatocellular carcinoma with hepatitis B virus infection

作　　者：林丽[1] 郑磊[1] 王前[1] 

机构地区：[1]南方医科大学南方医院检验科,广州510515

出　　处：《中华检验医学杂志》2013年第9期785-788,共4页Chinese Journal of Laboratory Medicine

摘　　要：微小RNA （miRNA）是片段长度约为22个核苷酸的高度保守的内源性非编码单链小RNA,广泛存在于动植物及病毒体内.成熟的miRNA通过使靶基因mRNA降解或特异性翻译抑制从而调节靶基因的表达,广泛参与生物体内的生理和病理过程.乙型肝炎病毒（HBV）X蛋白（HBX）是HBV病毒X基因编码的相对分子质量约为17000的蛋白质,与肝细胞癌的发生发展密切相关.近年来研究发现一些特异的miRNA受HBX调控,参与调节肝癌细胞的增殖、分化和凋亡等多个生物学过程.MicroRNAs （miRNAs） are evolutionarily conserved small noncoding RNAs of -22 nucleotides that exist in a wide variety of organisms, including animals, plants and virus. Mature miRNAs are able to control gene expression at a post-transcriptional level, either by blocking mRNA translation or inducing their degradation. Hepatitis B virus X protein （HBX） is a 17 000 protein that is implicated to play a crucial role in hepatocarcinogenesis. Recently, many studies have shown that HBX is associated with miRNA regulation, and is involved in regulating fundamental biological processes of tumor in cell proliferation, differentiation and apoptosis.

关 键 词：癌 肝细胞 反式激活因子类 微RNAS 细胞增殖 细胞凋亡 

分 类 号：R394[医药卫生—医学遗传学]