microRNAs与晶状体疾病的相关性研究进展  

Research advances in the relevance of microRNAs and lens diseases

作　　者：陈阳[1] 丁芝祥[1] 

机构地区：[1]桂林医学院附属医院眼科,中国广西壮族自治区桂林市541001

出　　处：《国际眼科杂志》2013年第10期2001-2003,共3页International Eye Science

基　　金：桂林市科学研究与技术开发计划项目(No.20130120-4)~~

摘　　要：microRNAs是一类长度约22个核苷酸的内源性非编码小RNA分子,广泛存在于真核细胞中,在细胞增殖、凋亡、分化、肿瘤发生以及机体代谢等一系列生命过程中扮演了重要角色,是近年来基因调控研究的热点。许多microRNAs广泛表达于眼部多种组织,并具有组织特异性和时序特异性,可能与眼部组织的生长、发育、功能调节、疾病发生等方面密切相关。研究microRNAs在晶状体发育和病理生理过程中的作用为进一步阐明晶状体疾病的发生机制、探索相关疾病的诊断和治疗方法提供了一种新思路。microRNAs are a class of endogenous non-protein- coding micromolecule RNAs with 22 nucleotides long, and are widely presented in the eukeryotic cells, which play a critical role in a series of life process, including cell proliferation, apoptosis, differentiation, tumorigenesis and individual metabolism. It has become a focus for gene regulation research in recent years. Most of microRNAs are widely expressed in various ocular tissues in the tissue specificity and time specificity mode, and may be closely involved in ocular tissue growth, development, functional regulation and diseases onset. To study the functions of microRNAs in lens development and pathophysiological process is to provide a new idea for further clarifying the mechanisms of lens diseases, exploring the dia.qnoses and treatments of the diseases.

关 键 词：MICRORNAS 基因表达 晶状体疾病 

分 类 号：R776[医药卫生—眼科]