翼状胬肉发病机制的研究进展  

Progress on pathogenesis of pterygium

作　　者：彭立[1,2] 谢青[1,2] 

机构地区：[1]中国海南省海口市人民医院眼科 [2]中南大学湘雅医学院附属海口医院,570208

出　　处：《国际眼科杂志》2013年第10期2007-2010,共4页International Eye Science

摘　　要：翼状胬肉是局部球结膜纤维血管组织增生侵犯角膜的一种疾病,是人类常见的眼表疾病之一,该病不仅直接影响面部美观,还可能由于牵拉引起眼部不适和散光,严重者影响视力且引起眼球运动障碍。关于该病的发病机制尚不明确,临床治疗以手术切除为主,但术后复发率较高。许多科学家对其发病机制提出了多种解释,创立了多种学说,但尚未有一种得到公认。明确认识翼状胬肉的发病机制,对于阻止翼状胬肉的发生、发展的研究具有重大的战略和现实意义。现就国内外在细胞凋亡抑制、基质金属蛋白酶、氧化应激、免疫方面的研究进行综述。Pterygium is one of the common ocular surface diseases, characterized by local subconjunctival fibrovascular proliferation invading the cornea, not only influences facial beauty, but affects visual acuity and causes ocular dyskinesia. Surgical removal is the main treatment option. However, the recurrence rate is high （20%- 40%）. Many explanations are put forward by scientists, but the mechanism of pterygium still remains unclear. It is of great importance to study the pathogenesis of pterygium so as to prevent its occurrence and development. In this paper, we make a review about the domestic and international studies of the inhibition of apoptosis, matrix metalloproteinase, oxidative stress and immunity in pterygium.

关 键 词：翼状胬肉 发病机制 氧化应激 基质金属蛋白酶 免疫 

分 类 号：R777.33[医药卫生—眼科]