玻璃酸钠和重组牛bFGF滴眼液在角膜铁锈异物取出术后的疗效  

Curative effect of Sodium hyaluronate and bFGF eye drops after corneal rust foreign body removal operation

作　　者：李金霞[1] 王彬[2] 包银兰[3] 

机构地区：[1]中国北京市房山区中医医院眼科,102488 [2]包头医学院第一附属医院眼科,中国内蒙古自治区包头市014010 [3]中国中医科学院望京医院眼科,中国北京市100102

出　　处：《国际眼科杂志》2013年第10期2099-2101,共3页International Eye Science

摘　　要：目的:观察比较玻璃酸钠滴眼液和重组牛碱性成纤维细胞生长因子滴眼液联合应用对角膜铁锈异物取出术后角膜创面上皮修复的临床效果。方法:选择角膜铁锈异物患者98例98眼,随机分成联合治疗组49例49眼和对照组49例49眼。联合治疗组于角膜异物取出术后滴玻璃酸钠滴眼液+重组牛碱性成纤维细胞生长因子滴眼液+盐酸左氧氟沙星滴眼液;对照组滴重组牛碱性成纤维细胞生长因子滴眼液+盐酸左氧氟沙星滴眼液。每周3次观察角膜荧光素染色、角膜创面上皮修复及患眼局部症状等指标,观察2wk。结果:联合治疗组的总有效率96%高于对照组的88%(P<0.05)。结论:玻璃酸钠滴眼液和重组牛碱性成纤维细胞生长因子滴眼液联合应用能明显促进角膜损伤后上皮修复速度,疗效确切,安全可靠。AIM： To observe the combined effect of Sodium hyaluronate eye drops and recombinant bovine basic fibroblast growth factor （bFGF） eye drops on cornea epithelial repair after corneal rust foreign body extraction. METHODS： Alinety-eight cases （98 eyes） of corneal rust foreign body patients were randomly distributed to combined treatment group （49 cases, 49 eyes） and control group （49 cases, 49 eyes）. Hyaluronate eye drops, recombinant bFGF eye drops and levofloxacin hydrochloride were applied in combined treatment group after corneal foreign body extraction. Recombinant bFGF eye drops and levofloxacin hydrochloride were applied in control group. Corneal fluorescein stain, cornea epithelial repair and local symptoms were examined thrice weekly for 2 weeks. RESULTS： General effective rate of treatment in combined group reach 96%, significantly higher than that in control group （88%, P〈0.05）. CONCLUSION： Combined application of sodium hyaluronate eye drops and recombinant bFGF eye dropscan prominently improve cornea epithelial repair after corneal lesion with proven effectiveness and safety.

关 键 词：角膜铁锈异物 玻璃酸钠滴眼液 重组牛碱性成纤维细胞生长因子滴眼液 角膜创面修复 

分 类 号：R779.1[医药卫生—眼科]