IL-33/ST2信号通路在纤维化疾病中的作用  

Role of IL-33 /ST2 signaling pathway in fibrosis diseases

作　　者：高巧艳[1] 李明才[1] 李燕[1] 王亚清[1] 高雪明[1] 袁仙丽[1] 

机构地区：[1]宁波大学医学院免疫学研究室,浙江宁波315211

出　　处：《中国病理生理杂志》2013年第9期1712-1717,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81070034);浙江省自然科学基金资助项目(No.LY13H090014);宁波市科技创新团队项目(No.2011B82014);宁波市重点学科项目(No.XKL11D2112;XKL11D2113);宁波大学研究生科研创新基金资助项目(No.G12JA004)

摘　　要：白细胞介素（interleukin，IL）33是Schmitz等通过计算机辅助手段发现的IL-1家族的第11个新成员，又被称为IL-1F11。IL-1家族还包括经典的细胞因子，如IL—1α、IL-1B和IL-18等。IL-33蛋白具有双重功能，它不仅作为细胞因子参与信号通路的转导，还作为核内转录因子参与基因表达的调节。Interleukin （IL）-33 is a member of IL-1 family. It is identified as a functional ligand for ST2 which is an IL-1 receptor-like protein. IL-33/ST2 signaling is involved in T-cell-mediated immune responses. Increasing evidence indicates that IL-33 has different roles in different diseases. Recently, some studies have demonstrated that IL-33 may be related to the genesis and development of fibrosis diseases. We review current knowledge of the biological characteristics of IL-33 and the role of IL-33/ST2 signaling pathway in fibrosis diseases.

关 键 词：白细胞介素33 ST2蛋白 纤维化疾病 

分 类 号：R363[医药卫生—病理学]