腺苷蛋氨酸联合前列腺素E1治疗重度黄疸型肝炎的临床观察  

Clinical Observation of Adenosylmethionine Combined with Prostaglandin E1 for Severe Icteric Hepatitis

作　　者：季丽杭[1] 雷虹[1] 吕伟旗[2] 陶勇军[3] 

机构地区：[1]丽水市中心医院,浙江丽水323000 [2]丽水市人民医院,浙江丽水323000 [3]丽水市中医院,浙江丽水323000

出　　处：《中国药房》2013年第36期3423-3425,共3页China Pharmacy

摘　　要：目的：观察腺苷蛋氨酸联合前列腺素E1治疗重度黄疸型肝炎的疗效和安全性。方法：选择98例重度黄疸型肝炎患者,随机均分为治疗组和对照组,对照组患者采用常规治疗,治疗组患者在对照组的基础上给予腺苷蛋氨酸1 000-1 500 mg加入10%葡萄糖注射液250 ml中静脉滴注,qd＋前列腺素E1100-200μg加入10%葡萄糖注射液250 ml中静脉滴注,qd。两组患者疗程均为4周。记录两组患者治疗前后血清丙氨酸氨基转移酶、凝血酶原活动度、总胆红素、白蛋白等实验室指标,观察两组患者治疗前、后的临床症状与体征,并观察两组患者不良反应发生情况。结果：治疗组患者治疗后血清丙氨酸转氨酶、总胆红素水平较对照组显著降低,凝血酶原活动度和白蛋白水平较对照组显著升高,差异均有统计学意义（P〈0.05）。治疗组患者治疗后总有效率显著高于对照组,两组比较差异有统计学意义（P〈0.05）。除脾脏回缩指标外,治疗组患者治疗后的临床症状与体征改善的有效率均显著优于对照组,两组比较差异有统计学意义（P〈0.05）。两组患者治疗期间均未见严重不良反应发生。结论：腺苷蛋氨酸联合前列腺素E1治疗重度黄疸型肝炎能改善患者肝功能,降低总胆红素,缩短凝血酶原时间,且安全性较好。OBJECTIVE：To observe therapeutic efficacy and safety of adenosylmethionine combined with prostaglandin E1 for severe icteric hepatitis.METHODS：98 cases of severe icteric hepatitis admitted were randomly divided into treatment group and control group.Control group was given conventional therapy;treatment group was addtionally given intravenous dripping of adenosylmethionine 1 000-1 500 mg added into 10% Glucose injection 250 ml,qd and prostaglandin E1 100-200 μg added into 10% Glucose injection 250 ml,qd on the basis of convetional treatment.Treatment course of 2 groups lasted for 4 weeks.Serum alanine aminotransferase,PTA,total bilirubin,albumin,clinical symptom and sign were observed in 2 groups before and after treatment.The occurrence of ADR was also observed.RESULTS：Compared with control group,serum alanine aminotransferase and total bilirubin of treatment group were decreased significantly after treatment.PTA and albumin were increased significantly;there was statistical significance（P0.05）.Total effective rate of treatment group was increased significantly after treatment;there was statistical significance（P0.05）.The improvement clinical symptoms and signs of treatment group were significantly superior to control group besides spleen retraction index;there was statistical significance（P0.05）.No severe ADR was found in 2 groups during treatment.CONCLUSIONS：Adenosylmethionine combined with prostaglandin E1 could improve liver function,reduce total bilirubin and shorten prothrombin time in the treatment of severe icteric hepatitis and is safe in the clinic.

关 键 词：腺苷蛋氨酸 前列腺素E1 重度黄疸型肝炎 

分 类 号：R575.1[医药卫生—消化系统]