抗溃疡性结肠炎药物4-氨基水杨酸衍生物对IL-13的作用  

The Effects of 4-aminosalicylic Acid(4-ASA) Derivative on IL-13

作　　者：李卫萍[1] 李元宏[1] 

机构地区：[1]山西医科大学汾阳学院,山西汾阳032200

出　　处：《中国医药指南》2013年第25期309-310,共2页Guide of China Medicine

摘　　要：目的观察4-氨基水杨酸衍生物对脂多糖诱导RAW264.7细胞产生IL-13的影响。方法设正常对照组、模型组(脂多糖组)、柳氮磺胺吡啶阳性对照组、4-氨基水杨酸衍生物低、中、高剂量组,给药24h后,ELISA检测上清中IL-13的含量。结果 4-氨基水杨酸衍生物在10、40、160μg/mL时均能促进IL-13的表达。结论 4-氨基水杨酸衍生物促进抑炎因子IL-13的表达。Objective To investigate the effects of 4-aminosalicylic acid （4-ASA） derivative on interleukin （IL）-13 in RAW264.7 cell induced by lipopolysaccharide（LPS）.Methods After the intervention was conducted on normal control group, model group,Sulfasalazine positive control group and 4-aminosalicylic acid derivative with low,medium and high dose group for 24 hours,the expressions of IL-13 were identified with enzyme-linked immunosorbent assay（ELISA）. Results Under the doses of 10,40,160 μg.ml-1, the concentration of IL-13 was promoted by 4-ASA derivative. Conclusion 4-ASA derivative promoted the concentration of IL-13.

关 键 词：4-氨基水杨酸衍生物 RAW264 7细胞 IL-13 

分 类 号：R574.62[医药卫生—消化系统]