国产脑深部电刺激系统治疗帕金森病的临床初步研究  

Clinical follow-up study of deep brain stimulation of idiopathic Parkinson＇s disease with domestic deep brain stimulation systems

作　　者：马羽[1] 孟凡刚[1] 胡文瀚[1] 葛明[2] 张凯[2] 杨岸超[2] 王慧敏[2] 张建国[2] 冯涛[3] 

机构地区：[1]首都医科大学北京市神经外科研究所 [2]首都医科大学附属北京天坛医院神经外科 [3]首都医科大学附属北京天坛医院神经内科

出　　处：《中华神经外科杂志》2013年第9期920-923,共4页Chinese Journal of Neurosurgery

基　　金：国家科技支撑计划，国家自然科学基金，北京市优秀人才

摘　　要：目的验证清华大学航天航空学院自主研发的国产脑深部电刺激（DBS）系统用于治疗原发性帕金森病（PD）临床应用的安全性和有效性。方法对33例PD患者实施1r国产脑深部电刺激系统（PINS系统）植入术。分别于术前、术后对用药情况，UPDRS评分量表，日常生活能力评分量表等情况进行评估和分析。结果33例PD患者平均年龄（56．3±8．6）岁，平均病程（10．4±4．3）年。术后患者症状均得到显著改善，UPDRS运动评分较术前改善78％，症状控制稳定。结论国产脑深部电刺激器PINS系统生物安全性、系统稳定性、刺激作用有效性均能够满足临床应用的要求。Objective To investigate the safety and efficacy of deep brain stimulation in idiopathic Parkinson＇s disease with domestic deep brain stimulation （DBS） systems, which were researched and developed by the School of Aerospace of Tsinghua University. Methods From November 2009 to Decemt）er 2011, 33 cases of patients with idiopathic Parkinson＇s disease were implanted with domestic deep brain stimulation system （PINS system） in Beijing Tiantan Hospital. During this study, preoperative, and 1, 3, 6, 9, 12 months postoperative assessments and analysis were done on each patient, which consisted of medication, UPDRS rating scale, and ADL Rating Scale situation, Results Among the 33 patients, The average age of them was 56.3 _＋ 8.6, mean duration of Parkinson＇s disease were 10. 4 _＋ 4.3 years. Their symptoms of PD improved significantly postoperatively, which maintained consistently. Compared with base line, UPDRS motor scores with stimulation both of ＂off ＂ state and ＂on＂ state had a reduction of 78 % and 78.8 % respectively 12 months after surgery. Conclusions Through the 12 months followed up of 33 cases of Parkinson＇s disease patients implanted with PINS system, the results confirmed the biological safety, stability and effectiveness of the PINS system, which was developed by the School of Aerospace, Tsinghua University. The results also showed that PINS system has met the requirements of clinical applications.

关 键 词：脑深部电刺激术 帕金森病 国产化 临床研究 

分 类 号：R742.5[医药卫生—神经病学与精神病学]