脑衰反应调节蛋白2及其与神经系统疾病关系的研究进展  

Advances of collapsin response mediator protein 2 and its relation to neural diseases

作　　者：张体栋[1] 尹艳玲[2] 李俊发[2] 

机构地区：[1]首都医科大学基础医学院 [2]首都医科大学基础医学院神经生物学系,北京100069

出　　处：《基础医学与临床》2013年第10期1332-1336,共5页Basic and Clinical Medicine

基　　金：国家自然科学基金(31200895);首都医科大学基础与临床合作课题(12JL44;12JL-L09)

摘　　要：脑衰反应调节蛋白2(CRMP2)在神经元发育过程中发挥着重要作用。CRMP2具有多种翻译后修饰方式和生物学功能,其中磷酸化修饰与神经系统疾病最相关,但其具体机制及生物学作用尚不清楚,有待进一步研究。CRMP2的研究为防治相关神经系统疾病提供了新的方向。Collapsin response mediator protein 2 （CRMP2） plays a crucial role in neuronal development. It owns lots of post-translational modifications, of which phosphorylation modification is related to diseases closely. CRMP2 also has many biological functions. There is a close relationship between CRMP2 and neurologic disorders, but the mechanism is required to be elucidated. The researche in CRMP2 provides some new strategies to prevent and cure the related diseases.

关 键 词：脑衰反应调节蛋白2 磷酸化 阿尔茨海默病 缺血低氧损伤 精神类疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]