粒细胞肉瘤9例临床分析及文献复习  

Clinical analysis and literature review of granulocytic sarcoma with nine cases report

作　　者：孙翠娥[1] 唐晓文[1] 孙爱宁[1] 仇惠英[1] 金正明[1] 傅琤琤[1] 马骁[1] 何广胜[1] 吴德沛[1] 

机构地区：[1]苏州大学附属第一医院血液科江苏省血液研究所卫生部血栓与止血重点实验室,苏州215006

出　　处：《上海交通大学学报（医学版）》2013年第9期1231-1234,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81270645);江苏省自然科学基金(BK2012627);江苏省高校自然科学研究(11KJB320015);江苏省卫生厅科研项目(H201125)~~

摘　　要：目的探讨粒细胞肉瘤(GS)的诊断和治疗方法。方法回顾性分析9例GS患者的临床表现、病理分型、诊断及治疗方法。结果 9例患者均以淋巴结肿大、结外软组织肿块为首发症状。以粒细胞分化和中幼阶段嗜酸粒细胞为GS的特征性病理表现,免疫组织化学检测多为髓过氧化酶、溶菌酶、CD43、CD34、CD56和CD15阳性表达。治疗方法有局部手术切除、放疗以及针对急性髓细胞白血病(AML)的全身性化疗方案。结论 GS的诊断依据为病变组织病理特点,免疫组织化学及骨髓形态学、免疫学分型、细胞遗传学、分子生物学检查,以明确为孤立型或已进展为AML,治疗上以局部手术切除、放疗以及全身性化疗为主。Objective To explore the diagnosis and the treatment options of granulocytic sarcoma （GS）. Methods The clinical manifestations, classification of pathological characteristics, diagnosis and treatment of 9 cases with GS were retrospectively analyzed. Results All of the 9 patients presented with lymphadenopathy and soft tissue mass as first symptoms. The pathological feature of GS was the differentiation of granulocytic and medium size mature eosinophils. The majority of GS patients exhibited positive immuno-histological results of myeloperoxidase, lysozyme, CD43, CD34, CD56 and CD15. The therapeutic options included local resection, radiation therapy and systemic chemotherapy with regimen of acute myeloid leukemia （AML）. Conclusion The diagnosis of GS depends on the pathologic feature, immunohistochemical characteristics of tissues, morphology, immunology, cytogenetics and molecular biology examinations of bone marrow, in order to define the type of GS （isolated type or AML）. The principle treatment options of GS are local resection, radiation therapy and systemic chemotherapy.

关 键 词：粒细胞肉瘤 诊断 治疗 

分 类 号：R733.7[医药卫生—肿瘤]