喉癌喉全切除术后造瘘口复发癌相关因素的Meta分析  

Meta-analysis on the risk factors for stomal recurrence after total laryngectomy

作　　者：盛晓丽[1,2] 张思毅[1,2] 宋新汉[1,2] 陈良嗣[1,2] 罗小宁[1,2] 

机构地区：[1]广东省人民医院耳鼻咽喉科 [2]广东省医学科学院,广州510080

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第18期995-999,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:系统评价喉癌喉全切除术后造瘘口复发的部分危险因素。方法:国内文献来源以喉癌、喉全切除术或全喉切除术、复发为关键词检索万方数据库、中文学术期刊全文数据库、维普中文生物医学期刊数据库,国外文献来源以laryngectomy、stomal recurrence为关键词检索Pubmed数据库、Embase数据库,手工检索所有纳入试验的参考文献,采用RevMan5.0软件对纳入文献的数据进行汇总分析(Meta分析)。结果:共纳入2篇中文文献,6篇英文文献,病例总数2 725例,造瘘口复发癌247例。全部入选病例造瘘口复发癌的发生率为9.06%。Meta分析结果显示原发于声门下区的肿瘤及跨声门型肿瘤、局部晚期的肿瘤(特别是T4)以及术前行气管切开术是喉全术后造瘘口复发的相关危险因素。结论:原发于声门下区的肿瘤及跨声门型肿瘤、局部晚期的肿瘤(T4)以及术前行气管切开术与喉癌喉全术后造瘘口复发有关。Objective： To evaluate the risk factors of stomal recurrence in patients after total laryngectomy. Method：A thorough literature search was performed among Wanfang database, Chinese Scientific Journals Database of VIP and pubmed database. Meta analysis was performed on a total of 2 725 patients in 2 Chinese papers and 6 English papers which met the inclusion criteria. Data was analyzed by RevMan 5.0 software. Result： Subglottic and transglottic location（tumor location）, the extent of the tumor of the primary site（T4）, preoperative tracheotomy were important risk factors of recurrence after total laryngectomy. Conclusion： Subglottic and transglottic location（tumor location）, the extent of the tumor of the primary site（T4）, preoperative tracheotomy were related to stomal recurrence after total laryngectomy.

关 键 词：喉肿瘤 喉全切除术 造瘘口复发 危险因素 META分析 

分 类 号：R739.65[医药卫生—肿瘤]