双氢青蒿素的抗肿瘤作用及机制  

The role and mechanism of anticancer of dihydroartemisinin

作　　者：贾立峰[1] 李晓明[1] 

机构地区：[1]白求恩国际和平医院耳鼻咽喉头颈外科全军耳鼻咽喉病诊疗中心,石家庄050082

出　　处：《临床耳鼻咽喉头颈外科杂志》2013年第18期1033-1036,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：双氢青蒿素（dihydroartemisinin，DHA）是抗疟药物青蒿素被硼氢化钠还原后的重要衍生物，也是治疗疟疾的主要活性成分，其为水溶性活性代谢物，其疗效强大而副作用小。相关研究已经证实，DHA除具有治疗疟疾、调节免疫、抗肝片形吸虫旺。及抗炎作用外，还能选择性杀伤肿瘤细胞、诱导肿瘤细胞凋亡及抑制肿瘤生长，有望成为一种经济高效的抗肿瘤新药。Summary Dihydroartemisinin（DHA） ,a semi-synthetic derivative of artemisinin, has recently shown antitu mor activity in various cancer cells including cancers of cervix, pancreas, prostate, liver and neuroblastoma. Nu- merous studies in vivo and in vitro indicate that DHA possesses unique antitumor features and appears to be a promising chemotherapeutic agents. Here we systematically review the advances in research of anticancer of di- hydroartemisinin,as well as summarize the mechanisms of its inducing apoptosis, delay cell-cycle, inhibitory cell proliferation and downregulate angiopoiesis.

关 键 词：双氢青蒿素 抗肿瘤 作用 机制 

分 类 号：R73[医药卫生—肿瘤]