广泛性焦虑症患者额中回、扣带回、海马磁共振质子波谱成像研究  

A ^1 H-magnetic resonance spectroscopy imaging study on frontal gyrus, anterior cingulate cortex and hip-pocampus of patients with generalized anxiety disorder

作　　者：魏杰[1] 王建安[2] 杨庚林[1] 张薇[1] 

机构地区：[1]新疆医科大学第一附属医院心理医学科,乌鲁木齐市830000 [2]新疆医科大学第一附属医院影像中心,乌鲁木齐市830000

出　　处：《中华行为医学与脑科学杂志》2013年第8期725-727,共3页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：新疆医科大学第一附属医院科研奖励基金（2010yfy23）

摘　　要：目的 探讨广泛性焦虑症患者（Generalized Anxiety Disorder,GAD）脑额中回、扣带回和海马功能.方法 19名符合ICD-10诊断标准的GAD患者为试验组,20名条件匹配的健康志愿者为对照组,用磁共振质子波谱成像技术（1 H-Magnetic Resonance Spectroscopy,1H-MRS）对所有入组者行脑额中回、扣带回和海马中胆碱化合物（Cho）、肌酸（Cr）、N-乙酰天冬氨酸（NAA）物质水平测定,并行两组间比较.结果 GAD组右额中回白质Cho（7.22±1.99）、Cr（5.44 ±1.68）、NAA（12.09±2.30）及右扣带回皮质Cho（9.89±2.40）、Cr（8.59±1.71）、左扣带回皮质NAA（13.49±2.27）明显高于对照组,差异具有统计学意义（P＜0.05）；两组右扣带回皮质NAA、左扣带回皮质Cho、Cr及左额中回白质Cho、Cr、NAA均差异无统计学意义（P＞0.05）；两组左右侧额中回白质及左右侧扣带回皮质中NAA/Cr、Cho/Cr均差异无统计学意义（均P＞0.05）；两组左、右侧海马的Cho、Cr、NAA、NAA/Cr,Cho/Cr均差异无统计学意义（P＞0.05）.结论 GAD患者脑物质代谢存在异常,且左右脑不对称,主要表现在右侧脑.Objective To study the feature of brain functional in front gyrus,anterior cingulate cortex and hippocampus of patients with generalized anxiety disorder （GAD）.Methods 19 patients with GAD and 20 healthy volunteers were scanned on brain using proton magnetic resonance spectroscopic imaging （1H-MRS）.The levels of Choline （Cho）,Creatine （Cr）,N-acetyl-aspartate （NAA） were measured in the frontal gyrus,anterior cingulate cortex and hippocampus of all subjects.The 1H-MRS data were compared between two groups.Results Compared with the healthy matched control,the levels of Cho （7.22 ± 1.99）,Cr （5.44 ± 1.68）,NAA （12.09 ±2.30）in right frontal gyrus white matter,the levels of Cho（9.89 ±2.40）,Cr（8.59 ± 1.71） in right anterior cingulate cortex and the levels of NAA in left anterior cingulate cortex were significantly high （P 〈 0.05）.The ratio of NAA/Cr and Cho/Cr were not difference in two groups.In the hippocampus of the patients,the Cho,Cr,NAA,NAA/Cr and Cho/Cr ratio were not significantly higher or lower than those in control （P 〉 0.05）.Conclusion The brain substance metabolisms of the patients with GAD are abnormal and asymmetrical between left and right brain,especially occurred in right brain.

关 键 词：磁共振质子波谱 广泛性焦虑症 额中回 扣带回 海马 

分 类 号：R749.72[医药卫生—神经病学与精神病学]