唑来膦酸治疗晚期前列腺癌骨转移性疼痛疗效分析  

Effect of zoledronic acid on bone metastasis pain from prostate cancer

作　　者：张广伟[1] 朱朝阳[1] 李铁强[1] 杜信毅[1] 李晓东[1] 

机构地区：[1]河南大学淮河医院,河南开封475000

出　　处：《中国实用医刊》2013年第20期32-33,共2页Chinese Journal of Practical Medicine

摘　　要：目的观察唑来膦酸治疗晚期前列腺癌骨转移性疼痛的疗效分析。方法85例疗晚期前列腺癌骨转移患者分治疗组55例和对照组30例，治疗组每次予唑来膦酸4mg加入100ml生理盐水中静脉滴注，静脉滴注15min，每4周1次，连续2次；对照组每次给予帕米膦酸二钠60mg加入生理盐水500ml静脉滴注，静脉滴注4h，每4周1次，连续2次。结果治疗组：CR占16．4％（9／55），PR占63．6％（35／55），MR占12．7％（7／55），NR占7．3％（4／55），CR＋PR为80．0％（44／55）。对照组：CR占16．7％（5／30），PR占60．0％（18／30），MR占13．3％（4／30），NR占10．0％（3／30），CR＋PR为76．7％（23／30）。与对照组相比止痛效果差异无统计学意义，均能使血中碱性磷酸酶水平明显降低。结论唑来膦酸治疗晚期前列腺癌骨转移性疼痛镇痛效果好，能明显改善患者生存质量。Objective To observe the efficacy of zoledronic acid on bone metastasis pain from prostate cancer. Methods A total of 85 cases of prostate cancer with bone metastasis who were evalu-able were enrolled and divided into the treatment group （55 cases） and the control group （30 cases）. The treatment group were treated with 4 milligram of zoledronic acid and the control group were treated with 60 milligram of pamidronate disodium every 4 weeks. Treatment efficacy were evaluated after 2 cy-cles. Results In the treatment group, 9 cases （ 16. 4% ） bad complete response （ CR）, and 35 cases （63.6%） had partial response （PR） for relief of bone pain, and in the controll group, 5 cases （ 16.7% ） had CR and 18 cases （60. 0% ） had PR. There was no significant difference in clinical effica-cy between the two groups and they both can decrease the level of alkaline phosphatase in blood. Conclu-sions Zoledronic acid has good analgesia effect on bone metastasis pain of prostate cancer and is more convenient than pamidronate disodium in application.

关 键 词：唑来膦酸 前列腺癌 骨转移性疼痛 

分 类 号：R737.25[医药卫生—肿瘤]