结直肠癌患者应用奥沙利铂化疗引起神经炎的临床预测因素分析  

Clinical predictive factor of oxaliplatin-induced peripheral neuropathy in colorectal cancer pa-tients

作　　者：王小艳 王志伟 袁琛 李海鹰 

机构地区：[1]山东省青岛市中心医院干部保健科,266042 [2]山东省青岛市中心医院普外科,266042 [3]山东省青岛市中心医院急救中心,266042

出　　处：《中国实用医刊》2013年第20期71-73,共3页Chinese Journal of Practical Medicine

摘　　要：目的研究可能预测神经炎发生和发展的可靠临床因素。方法回顾2005年1月至2011牟12月期间在青岛市中心医院结直肠癌根治术后行Folfox Ⅳ方案辅助性化疗的171名患者，所有患者在化疗前均有完善的化验检查，详细记录其姓名、年龄、性别、民族、结直肠癌临床分期、病理类型、血红蛋白、白蛋白、糖尿病、血浆钙、镁水平，血肌酐水平，并记录患者既往史中是否有饮酒及吸烟史和周围神经炎的发病情况、程度和持续时间。结果应用奥沙利铂化疗后贫血、低蛋白血症、低镁血症和有饮酒史患者周围神经炎的发病率明显升高。结论贫血、低蛋白血症、低镁血症和饮酒史是能够预测奥沙利铂化疗引起的周围神经炎的可靠而容易获得的临床因素，对这些因素的预处理可能会减少神经炎的发病率，减轻患者的痛苦。Objective To identify the reliable clinical factors for predicting the occurence and development of neuropathy. Methods One hundred and seventy-one completely resected colorectal cancer patients treated with Folfox Ⅳ regimen were retrospectively included. All the patients received complete clinical examination before chemotherapy. The following clinical parameters were collected： name, age, gender, nation, clinical stage of colorectal cancer, pathology, hemoglobin level, albumin level, diabetes, calcium level, magnesium level, creatinine level, habit to alcohol and tobacco consump-tions. Incidence, grade and duration of neurophathy were recorded. Results Incidence of neuropathy was found to be higher in patients with pretreatment anaemia, hypoalbuminaemia, and hypomagnesaemia as well as in those with habit of alcohol consumpsion. Conclusions Age, anaemia, hypoalbuminaemia, hypomagnesaemia and alcohol consumption are reliable and easily assessable clinical factors for predicting the incidence and length of oxaliplatin-induced neuropathy. Pretreatment of clinical factors before ehemo- therapies can reduce the morbidity of neuropathy and relieve the suffering of the patients.

关 键 词：结直肠癌 奥沙利铂 周围神经炎 预测因素 

分 类 号：R735.3[医药卫生—肿瘤]