镰刀菌毒素生殖发育毒性研究进展  

Review of reproductive and developmental toxicity studies of Fusarium toxins

作　　者：郭隽[1,2] 张立实[1] 彭双清[3] 

机构地区：[1]四川大学华西公共卫生学院,四川成都610041 [2]中国食品药品检定研究院国家药物安全评价监测中心,北京1001763 [3]军事医学科学院疾病预防与控制所,北京100071

出　　处：《中国食品卫生杂志》2013年第5期474-478,共5页Chinese Journal of Food Hygiene

基　　金：国家科技重大专项资助项目(2009ZX09501-034)

摘　　要：镰刀菌毒素是指镰刀菌属的毒性代谢产物,其中单端孢霉烯族毒素是粮食中最常见的一类污染性镰刀菌毒素,可以引起人或动物急性、慢性毒性作用,部分霉菌毒素已证明具有致突变性及致癌性。流行病学及体内、体外实验研究结果表明,部分镰刀菌毒素对人或动物生殖细胞、受孕、妊娠、分娩、哺乳等亲代生殖机能以及对其子代胚胎-胎儿发育、出生后发育产生不良影响。本文对镰刀菌毒素生殖、发育毒性研究及其进展进行综述。Fusarium toxins,the metabolites of trichothecenes,zearalenone and fumonisins,are widespread in cereals and their products which can cause toxic effects through oral chronic exposure to human and animals.Fusarium toxins also have specific toxic effects,such as metabolism disorders,liver toxicity,kidney toxicity,neurotoxicity,skin phototoxicity,hematopoietic toxicity and so on.Mycotoxins have been shown to have mutagenic and carcinogenic effects and some fusarium toxins can cause reproductive and developmental toxicities to human and animals.This paper reviews the reproductive and developmental toxicity of fusarium toxins on human and animal.

关 键 词：镰刀菌毒素 生殖毒性 发育毒性 食品污染物 

分 类 号：R114[医药卫生—卫生毒理学]