Rho通路与肺高血压研究进展  

Rho-pathway in pulmonary arterial hypertension

作　　者：程春燕[1] 吴丹辰[1] 荆志成[1,2] 

机构地区：[1]同济大学附属上海市肺科医院心肺循环中心,200433 [2]中国医学科学院阜外心血管病医院心血管疾病国家重点实验室血栓性疾病诊疗中心,北京100037

出　　处：《国际呼吸杂志》2013年第19期1507-1511,共5页International Journal of Respiration

摘　　要：针对RhoA及Rho激酶的研究揭示了其通路激活与肺血管病理生理改变相关，包括肺血管重塑如内膜功能失调、中膜平滑肌细胞增生及收缩舒张调节等。本文旨在回顾Rho激酶结构、调控通路及其介导肺血管重塑的病理生理学机制，归纳Rho激酶抑制剂治疗肺高血压的作用机制及其在动物模型和临床研究中的初步结果。During the past few decades, studies have revealed the relationship between RhoA/Rho- kinase signaling pathway and the pathophysiological process in pulmonary vascular diseases. The pathway has an intensive involvement in pulmonary vascular remodeling, including endothelial dysfunction, smooth muscle cell hypertrophy and proliferation. So the aim of this review is to introduce the structure of Rho-kinase, how it regulates, and the pathophysiological mechanisms of Rho-kinase-mediated vascular remodeling. The underlying mechanisms of Rho-kinase inhibitor attenuating pulmonary hypertension （PH）, as well as the therapeutic effect of Fasudil-a selective Rho-kinase inhibitor on PH animal model and patients are also discussed.

关 键 词：RHO激酶 肺高血压 病理生理 法舒地尔 

分 类 号：R363[医药卫生—病理学]