卒中神经保护研究:过去,现状与未来  

Research on Neuroprotective Strategy of Stroke: The Past, Present and Future

作　　者：刘勇[1] 冯国栋[1] 张光运[1] 韩军良[1] 赵钢[1] 

机构地区：[1]第四军医大学西京医院神经内科,西安710032

出　　处：《中国卒中杂志》2013年第9期768-772,共5页Chinese Journal of Stroke

基　　金：国家"重大新药创制"科技重大专项(2008ZX09lO1.026);陕西省社发攻关基金(省2012K15-02-06)

摘　　要：目前正在进行的卒中神经保护策略研究主要有白蛋白、镁和低温治疗等;一些有前景的神经保护剂如人参皂苷Rd(ginsenoside Rd,GSRd)、突触后膜密95蛋白阻断剂NA-1(a 20-amino acid peptide,Tat-NR2B9c)等的研究还在探索中。神经保护研究的30年经历了由高潮到低谷再到新高潮的发展阶段,而未来神经保护治疗的研究要取得更好的发展需注重:动物实验中的严格设计,研究对象应从龋齿动物向灵长类动物转化,评价方法由行为评估向影像学评估转变;而整体研究范式应扩展到血管神经网络。Many ongoing studies of neuroprotective strategy of stroke include albumin,magnesium and cryotherapy therapy.There are also a number of promising neuroprotectants in preclinical development including ginsenoside Rd,NA-1（Tat-NR2B9c）,an inhibitor of postsynaptic density-95 protein etc.Thirty years＇ study of neuroprotective strategy of stroke experiences the development process from the peak to the trough then to new climax.However,to achieve better development,future research should focus on：conduct a strict design;the object of study should converse from dental caries animal to primate;the evaluation method should converse from behavioral assessment to radiographic evaluation;research paradigm should extend to vascular neural network.

关 键 词：卒中 神经保护策略 人参皂苷RD 

分 类 号：R743.3[医药卫生—神经病学与精神病学]