补阳还五汤常压煎煮工艺优选  

Optimization of Atmospheric Pressure Boiling Technology of Buyang Huanwu Decoction

作　　者：张源 周琴妹 刘顺 朱其辉 蔡宝昌[2] 

机构地区：[1]南京中医药大学附属医院制剂部,南京210029 [2]南京中医药大学,南京210046

出　　处：《中国实验方剂学杂志》2013年第19期5-8,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中医药行业科研专项(201007010)

摘　　要：目的:考察两煎常压煎药机不同煎煮条件对补阳还五汤剂质量的影响。方法:采用单因素试验考察加水量水平,以总固体、阿魏酸及黄芪甲苷含量为综合评价指标,通过正交试验考察加水量、浸泡时间、煎煮次数及煎煮时间对煎煮工艺的影响,利用HPLC测定阿魏酸及黄芪甲苷含量。结果:方差分析表明各因素对煎煮工艺的影响顺序为煎煮次数>加水量>煎煮时间>浸泡时间,其中煎煮次数具有显著性影响,其余3个因素均无显著性影响。最佳常压煎煮工艺为加8～10倍量水浸泡30 min,煎煮2次,每次60 min。结论:优选的工艺稳定可行,为两煎常压煎药机制备含黄芪甲苷及阿魏酸的中药汤剂提供理论依据。Objective： To investigate effects of different boiling conditions on quality of Buyang Huanwu decoction by double decocting non-pressurized machine. Method： A single factor test was adopted to investigate levels of adding water, with the contents of total solids, ferulic acid and astragaloside as comprehensive evaluation index, effects of soaking time, the amount of water, boiling times and time on technology were investigated by orthogonal test. The contents of ferulic acid and astragaloside were determined by HPLC. Result： Analysis of variance showed that effect of factors on boiling technology was in order of decoction times 〉 the amount of water 〉 decoction time 〉 soaking time, only decoction times had significant impact. Optimum non-pressurized boiling technology was as following： soaked 30 min with 8-10 times the amount of water, decoction for 2 times, 60 min per time. Conclusion： Optimized technology was stable and feasible, it provided theoretical basis for ferulic acid and astragaloside as main ingredients in traditional Chinese medicine decoctions.

关 键 词：补阳还五汤 常压煎药机 工艺优选 正交试验 高效液相色谱 阿魏酸 黄芪甲苷 

分 类 号：R283.6[医药卫生—中药学] R284.2[医药卫生—中医学]