肝动脉化疗栓塞分别联合经皮微波凝固治疗与125I放射性粒子植入治疗原发性大肝癌的疗效观察  

Comparing the therapeutic efficacy of TACE combined with psychro-circulation percutaneous microwave coagulation therapy or radioactive125I particle implantation to treat large primary liver cancer

作　　者：张世杰[1] 马亦龙[1] 康平[1] 蒙志斌[1] 李志坤[1] 欧盛秋[2] 齐锋[1] 赵昌[1] 

机构地区：[1]广西医科大学附属肿瘤医院介入治疗科,南宁530021 [2]南宁广西医科大学附属肿瘤医院介入治疗科,530021

出　　处：《中国癌症防治杂志》2013年第3期246-249,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

摘　　要：目的评价和比较肝动脉化疗栓塞(TACE)联合经皮微波凝固治疗(PMCT)与TACE联合125I放射性粒子植入治疗原发性大肝癌的效果。方法 46例原发性大肝癌患者接受TACE联合PMCT治疗,20例接受TACE联合125I放射性粒子植入治疗。术后2个月、3个月分别行动态增强CT复查。观察并比较两组疗效、毒副反应及并发症发生的情况。结果综合治疗后3个月,TACE联合PMCT组的有效率为82.61%,明显高于TACE联合125I放射性粒子植入组的有效率55.00%(P<0.05)。两组的临床总控制率分别为93.47%、85.00%(P>0.05)。两组发生的毒副反应无明显差异,均未出现严重并发症。结论 TACE联合PMCT及TACE联合125I放射性粒子植入均为原发性大肝癌安全、有效的治疗方法,两组毒副反应及并发症的发生率相当,前者治疗效果较为理想,值得临床应用。Objective To compare the therapeutic efficacy of transcatheter arterial chemoembolization （TACE） combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive ^125I particle implantation for treating large primary liver cancer （LPLC）. Methods A total of 46 patients with LPLC underwent TACE and psychro-circulation percutaneous microwave coagu- lation therapy using the ECO-100 system, while 20 patients underwent TACE and radioactive ^125I particle implantation.At 2 and 3 months after treatment, patients were analyzed by dynamic enhanced computed tomography scanning,and adverse reactions and complications were recorded. Results At 3 months after treatment,TACE combined with psychro-circulation percutaneous microwave coagulation therapy gave a local control rate of 82.61%, compared to 55.00% for TACE combined with radioactive ^125I particle implantation （P〈0.05）. The two methods gave similar clinical control rates of 93.47% and 85.00%, respectively （P〉0.05）.In addition, the two groups did not differ significantly in adverse reactions, and neither group showed serious complications. Conclusion TACE combined with either psychro-eirculation percutaneous microwave coagulation therapy or radioactive ^125I particle implantation is effective for treating LPLC,and both methods cause similar adverse reactions.Of the two combination therapies,TACE combined with psychro-circulation percutaneous microwave coagulation therapy is more effective for treating LPLC.

关 键 词：肝肿瘤 化学栓塞 微波消融 125I放射性粒子 疗效 

分 类 号：R735.7[医药卫生—肿瘤]