硫化氢在脑缺血-再灌注损伤中的作用  

Effects of hydrogen sulfide on cerebral ischemia-reperfusion injury

作　　者：刘蓓蓓[1] 

机构地区：[1]430030,湖北,武汉,华中科技大学同济医学院附属同济医院急诊科

出　　处：《中国急救医学》2013年第9期847-851,共5页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金资助项目（81071526）

摘　　要：硫化氢（H2S）是继一氧化氮（NO）和一氧化碳（CO）后新发现的第三种内源性气体信号分子,在机体内发挥广泛的生物学效应.已有实验证实,H2S参与多个器官缺血-再灌注损伤的病理生理过程,H2S在心肌缺血-再灌注损伤中的作用已有深入研究,但在脑缺血-再灌注损伤中的作用尚未明确阐述.本文主要基于现有的相关文献,旨在阐明H2S与脑缺血-再灌注损伤的关系,并论述其可能的细胞和分子学机制.Hydrogen sulfide （H2S） is the third kind of endogenous gaseous signal molecules newly discovered after nitric oxide and carbon monoxide, and plays a wide range of biological roles in the body. It has been proved that H2S participates in the pathophysiological process of multiple organ ischemia -reperfusion injury. However, the effects of H2S on cerebral ischemia -reperfusion injury have not been clearly clarified. This paper intends to illustrate the relationship between H2 S and cerebral ischemia- reperfusion injury based on the current literatures, and discuss the possible cellular and molecular mechanisms.

关 键 词：硫化氢（H2S） 脑缺血-再灌注损伤 线粒体 亚低温 细胞信号通路 

分 类 号：R743.3[医药卫生—神经病学与精神病学]