mTOR信号通路与衰老  

mTOR Signal Pathway and Aging

作　　者：陈金晶[1] 占跃晨 高瑞娟[1] 邓洪斌[1] 李电东[1] 王真[1] 

机构地区：[1]中国医学科学院北京协和医学院医药生物技术研究所,中国北京100050

出　　处：《国际老年医学杂志》2013年第5期212-217,共6页International Journal of Geriatrics

基　　金：国家自然科学基金项目（81072645 810010021）科技部＂十二五＂创新药物研究开发技术平台建设＂生物药物药效与药理学＂（2012ZX09301002-001-015）协和青年科研基金项目（2012）

摘　　要：哺乳动物雷帕霉素靶蛋白（mammalian target of rapamycin,mTOR）是一种进化上十分保守的丝氨酸/苏氨酸蛋白激酶,能对氨基酸、应激、氧、能量和生长因子等信号作出应答,并将信号传导到下游,最终调节细胞的生长和增殖.近几年研究发现,降低无脊椎模式生物中TOR通路的活性可增加寿命,雷帕霉素可延长实验鼠的寿命。Mammalian target of rapamycin （mTOR） , as an evolutionarily conservative serine/threonine protein kinase, can integrate the signal inputs from amino acids, stress, oxygen, energy and growth factor. It can furthermore relay the signal to downstream and uhialately regulate cell growth and proliferation. Research in recent years have found that inhibiting the activity of TOR pathway in the invertebrate model organisms can extend their life span. Rapamycin, an inhibitor of roTOR, can prolong the life span of mice. Collectively, which indicates that roTOR pathway may have a close relation with the regulation of aging. Study on the rela-tionship between roTOR pathway and aging as well as the regulation mechanisms involved may be helpful for delaying a great deal of pathological development and finally extending human life span.

关 键 词：MTOR 信号通路 衰老 

分 类 号：R542.2[医药卫生—心血管疾病]