Moving RNA moves RNA forward  

作　　者：PENG LiNa LI YuJiao ZHANG Lan YU WenQiang 

机构地区：[1]Key Laboratory of Ministry of Education,Department of Molecular Biology,Fudan University [2]EpiRNA Laboratory,Institutes of Biomedical Sciences,Shanghai Medical College,Fudan University [3]School of Basic Medical Sciences,Shanghai Medical College,Fudan University

出　　处：《Science China(Life Sciences)》2013年第10期914-920,共7页中国科学（生命科学英文版）

基　　金：supported by the National Basic Research Program of China(2009CB825603,2012CB517605);National Natural Science Foundation of China(81272392)

摘　　要：Cell communication affects all aspects of cell structure and behavior,such as cell proliferation,differentiation,division,and coordination of various physiological functions.The moving RNA in plants and mammalian cells indicates that nucleic acid could be one of the various types of messengers for cell communication.The microvesicle is a critical pathway that mediates RNA moving and keeps moving RNA stable in body fluids.When moving miRNA enters the target cell,it functions by altering the gene expression profile and significantly inhibiting mRNA translation in recipient cells.Thus,moving RNA may act as a long-range modulator during development,organogenesis,and tumor metastasis.Cell communication affects all aspects of cell structure and behavior, such as cell proliferation, differentiation, division, and coordination of various physiological functions. The moving RNA in plants and mammalian cells indicates that nucleic acid could be one of the various types of messengers for cell communication. The microvesicle is a critical pathway that mediates RNA moving and keeps moving RNA stable in body fluids. When moving miRNA enters the target cell, it functions by altering the gene expression profile and significantly inhibiting mRNA translation in recipient cells. Thus, moving RNA may act as a long-range modulator during development, organogenesis, and tumor metastasis.

关 键 词：cell communication moving RNA MICROVESICLE 

分 类 号：Q522[生物学—生物化学] TP393[自动化与计算机技术—计算机应用技术]