MICROVESICLE

作品数：18被引量：336H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：李润生赵茹茜杨晓静贾逸敏张辰宇更多>>
相关机构：南京大学南京农业大学更多>>
相关期刊：《Science China(Life Sciences)》《Acta Pharmacologica Sinica》《分子诊断与治疗杂志》《Genes & Diseases》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金更多>>
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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles被引量：3
《Military Medical Research》2024年第1期1-18,共18页Zi-Sen Zhang Yi-Yan Liu Shuang-Shuang He Dai-Qin Bao Hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu Zhu Yue Wu Qing-Hui Li Tao Li Liang-Ming Liu 
supported by the Key Projects and Innovation Group of National Natural Science Foundation of China(81830065),the Innovation Groups of NSFC(81721001),and the Young Scientists Fund(82102279).
Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis.We hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity...
关键词：PERICYTE Vascular reactivity Vascular permeability CX43 MICROVESICLE 
Microvesicles(MIVs)secreted from adipose-derived stem cells(ADSCs)contain multiple microRNAs and promote the migration and invasion of endothelial cells被引量：9
《Genes & Diseases》2020年第2期225-234,共10页Bo Huang Lin-Feng Huang Ling Zhao Zongyue Zeng Xi Wang Daigui Cao Lijuan Yang Zhenyu Ye Xian Chen Bin Liu Tong-Chuan He Xiaozhong Wang 
The reported work was supported in part by research grants from the Natural Science Foundation of Jiangxi Province China(#20151BAB215005);the Natural Science Foundation of China(#81660029,81360083);TCH was also supported by the Mabel Green Myers Research Endowment Fund,USA and The University of Chicago Orthopaedics Alumni Fund,USA.Funding sources were not involved in the study design;in the collection,analysis and interpretation of data,in the writing of the report;and in the decision to submit the paper for publication.
Extracellular vesicles(EVs)such as microvesicles(MIVs)play an important role in intercellular communications.MIVs are small membrane vesicles sized 100e1000 nm in diameter that are released by many types of cells,such...
关键词：Adipose-derived stem cells(ADSCs) Angiogenesis Let-7 microRNA Microvesicle(MIV) 
Exosomes: a novel therapeutic target for Alzheimer's disease?被引量：9
《Neural Regeneration Research》2018年第5期930-935,共6页Zhi-You Cai Ming Xiao Sohel H.Quazi Zun-Yu Ke 
financially supported by the Health and Family Planning Scientific Research Project of Hubei Province of China,No.WJ2015MB219
Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as multivesicular bodies. Thus, exosomes contain cytoplasmic content. Multivesicular bodies fuse with the plasma membrane and relea...
关键词：nerve regeneration MICROVESICLE BETA-AMYLOID tau NEUROINFLAMMATION oxidative stress therapeutic target NEURODEGENERATION DEMENTIA neural regeneration 
BCR-ABLl-positive microvesicles malignantly transform human bone marrow mesenchymal stem cells in vitro被引量：2
《Acta Pharmacologica Sinica》2017年第11期1475-1485,共11页Fen-fen FU Xiao-jian ZHU Hong-xiang WANG Li-ming ZHANG Guo-lin YUAN Zhi-chao CHEN Qiu-bai LI 
This work was supported by grants from the National Natural Science Foundation of China to Qiu-bai LI （No 81272624 and 81071943） and to Zhi-chao CHEN （No 81170497）.
The intercellular communication between leukemia cells and bone marrow mesenchymal stem cells （BM-MSCs） plays more important role in chronic myeloid leukemia （CML） than we previously understood. Recently, we found...
关键词：chronic myeloid leukemia MICROVESICLE bone marrow mesenchymal stem cell BCR-ABL1 TGF-β1 
Adipocyte-derived microvesicles from obese mice induce M1 macrophage phenotype through secreted miR-155被引量：20
《Journal of Molecular Cell Biology》2016年第6期505-517,共13页Yaqin Zhang Hongliang Mei Xiaoai Chang Fang Chen Yunxia Zhu Xiao Han 
supported by research grants from the Ministry of Science and Technology(2012CB524900);the National Natural Science Foundation of China(81400787);the Natural Science Foundation of Jiangsu Province,China(BK20130890);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(13KJB320013);the Specialized Research Fund for the Doctoral Program of Higher Education,China(20133234120006).
The pro-inflammatory profile of M1 macrophage accumulation in adipose tissue is a central event leading to the metabolic complications of obesity.However,the mechanisms by which M1 macrophages are enriched in adipose ...
关键词：ADIPOCYTE MACROPHAGE PHENOTYPE MICROVESICLE MIR-155 
The role of exosomes in peripheral nerve regeneration被引量：11
《Neural Regeneration Research》2015年第5期743-747,共5页Rosanna C.Ching Paul J.Kingham 
supported by grants from the Swedish Research Council,European Union and Umea University(Insamlingsstiftelsen)
Peripheral nerve injuries remain problematic to treat, with poor functional recovery commonly observed. Injuries resulting in a nerve gap create specific difficulties for axonal regeneration. Approaches to address the...
关键词：axonal regeneration EXOSOME extracellular vesicle microRNA MICROVESICLE nerve gap neurite outgrowth peripheral nerve injury Schwann cell stem cell 
Detection of Microvesicle miRNA Expression in ALL Subtypes and Analysis of Their Functional Roles被引量：3
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2014年第5期640-645,共6页李雯英 陈小梅 熊薇 郭冬梅 卢力 李慧玉 
supported by the National Natural Science Foundation of China(No.81170462)
Microvesicles （MVs） are the heterogeneous mixtures of vesicles. MVs released by leukemia cells constitute an important part of the leukemia microenvironment. MVs might act as important reser- voirs of microRNAs （mi...
关键词：MICROVESICLES miRNA expression profiles acute lymphoblastic leukemia subtypes 
Tumor-secreted miR-214 induces regulatory T cells： a major link between immune evasion and tumor growth被引量：36
《Cell Research》2014年第10期1164-1180,共17页Yuan Yin Xing Cai Xi Chen Hongwei Liang Yujing Zhang Jing Li Zuoyun Wang Xiulan Chen Wen Zhang Seiji Yokoyama Cheng Wang Liang Li Limin Li Dongxia Hou Lei Dong Tao Xu Takachika Hiroi Fuquan Yang Hongbin Ji Junfeng Zhang Ke Zen Chen-Yu Zhang 
We thank ProfAlexander Rudensky （Memorial Sloan-Kettering Cancer Center, New York） for diphtheria toxin-treated Foxp3DrR mice. We thank Drs Zheng-Gang Liu （Cancer Research Institute, NIH） and Dan Wu （Yale University） for their comments on the manuseirpt. This work was supported by grants from the National Basic Research Program of China （973 Program; 2014CB542300）, the National Natural Science Foundation of China （81101330, 31271378 and 81250044）, the Natural Science Foundation of Jiangsu Province （BK2011013 and BK2012014） and the Research Special Fund for Public Welfare Industry of Health （201302018）. This work was also supported by the program for New Century Excellent Talents in University from the Ministry of Education of China （NCET- 12-0261）.
An increased population of CD4＋CD25highFoxp3＋ regulatory T cells （Tregs） in the tumor-associated microenvi- ronment plays an important role in cancer immune evasion. However, the underlying mechanism remains uncle...
关键词：secreted microRNA regulatory T cell PTEN MICROVESICLE immune evasion TUMOR 
Therapeutic effects of mesenchymal stem cell-derived microvesicles on pulmonary arterial hypertension in rats被引量：21
《Acta Pharmacologica Sinica》2014年第9期1121-1128,共8页Jian-ying CHEN Ran AN Zhen-jun LIU Jin-ju WANG Shu-zhen CHEN Mian-ming HONG Jing-hu LIU Meng-yuan XIAO Yan-fang CHEN 
Aim： Microvesicles （MVs） are nanoscale membrane fragments released from virtually all cell types upon activation or apoptosis, and may contribute to the beneficial effects of stem cell therapy. In this study, we in...
关键词：stem cell therapy bone marrow mesenchymal stem cell MICROVESICLE pulmonary artery hypertension chronic heart disease 
Potential advantages of acute kidney injury management by mesenchymal stem cells被引量：5
《World Journal of Stem Cells》2014年第5期644-650,共7页Francesca Bianchi Elisa Sala Chiara Donadei Irene Capelli Gaetano La Manna 
Mesenchymal stem cells are currently considered as a promising tool for therapeutic application in acute kidney injury(AKI) management. AKI is characterized by acute tubular injury with rapid loss of renal function. A...
关键词：Mesenchymal stem cells PARACRINE Soluble factors MICROVESICLE Acute kidney injury Regenerative medicine PRECLINICAL Clinical trial 
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