PARACRINE

作品数：50被引量：290H指数：9
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相关领域：医药卫生更多>>
相关作者：卢森刘艾然邱海波杨毅陈齐红更多>>
相关机构：东南大学纽约州立大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Reproductive and Developmental Medicine》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省自然科学基金更多>>
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Hormonally and chemically defined expansion conditions for organoids of biliary tree Stem Cells
《Bioactive Materials》2024年第11期672-695,共24页Wencheng Zhang Yangyang Cui Mengqi Lu Mingyang Xu Yuting Li Haimeng Song Yi Luo Jinjia Song Yong Yang Xicheng Wang Lijun Liao Yunfang Wang Lola Reid Zhiying He 
Major Program of National Key Research and Development Project(2020YFA0112600,2019YFA0801502);National Natural Science Foundation of China(82173019,82270638,8220374,82300718);Project of Shanghai Science and Technology Commission(22ZR1451100,22Y11908500);Peak Disciplines(Type IV)of Institutions of Higher Learning in Shanghai,and Shanghai Engineering Research Center of Stem Cells Translational Medicine(20DZ2255100).
Wholly defined ex vivo expansion conditions for biliary tree stem cell(BTSC)organoids were established,consisting of a defined proliferative medium(DPM)used in combination with soft hyaluronan hydrogels.The DPM consis...
关键词：Biliary tree stem cells(BTSCs) ORGANOIDS Paracrine signals Defined Proliferative Medium(DPM) BTSC-Expansion-Glycogel(BEX-gel) 
Paracrine function amplifies pro-tumor electrochemical signal within neuron-glioma synapses
《Science China(Life Sciences)》2024年第6期1318-1320,共3页Yan Hu Peishan Hu Xiaozhong Peng 
supported by the National Natural Science Foundation of China(82003102)。
Neuronal activity plays a pivotal role in various physiological processes,including tissue development,homeostasis,and adaptability.Advances in recent years have improved our understanding of neuronal activity in brai...
关键词：GLIOMA HOMEOSTASIS FUNCTION 
A Polyvinyl Alcohol/Acrylamide Hydrogel with Enhanced Mechanical Properties Promotes Full-Thickness Skin Defect Healing by Regulating Immunomodulation and Angiogenesis Through Paracrine Secretion被引量：1
《Engineering》2024年第6期138-151,共14页Peng Wang Liping Qian Huixin Liang Jianhao Huang Jing Jin Chunmei Xie Bin Xue Jiancheng Lai Yibo Zhang Lifeng Jiang Lan Li Qing Jiang 
supported by the National Natural Science Foundation of China(32271413 and 32271408);the National Basic Research Program of China(2021YFA1201404);the Natural Science Foundation of Jiangsu Province(BK20232023);the Science Program of Jiangsu Province Administration for Market Regulation(KJ2024010);the Jiangsu Provincial Key Medical Center Foundation,and the Jiangsu Provincial Medical Outstanding Talent Foundation.
Hydrogel-based tissue-engineered skin has attracted increased attention due to its potential to restore the structural integrity and functionality of skin.However,the mechanical properties of hydrogel scaffolds and na...
关键词：Polyvinyl alcohol/acrylamide hydrogel Mechanical property enhancement Paracrine effect Skin regeneration Signaling pathways 
The secretory function of adipose tissues in metabolic regulation被引量：1
《Life Metabolism》2024年第2期9-23,共15页Yang Liu Shu-Wen Qian Yan Tang Qi-Qun Tang 
supported by the National Key R&D Program of China(grant 2018YFA0800400 to Q.Q.T.);the National Natural Science Foundation of China(NSFC)(grants 82370881,82170884,and 81970744 to Y.L.);Shanghai Rising-Star Program(grant 22QA1402100 to Y.L.).
In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in resp...
关键词：ADIPOKINES AUTOCRINE PARACRINE ENDOCRINE metabolic regulation 
Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions被引量：1
《Genes & Diseases》2024年第2期874-889,共16页Yancheng Lai Xiaole Lu Yankai Liao Pei Ouyang Hai Wang Xian Zhang Guanglong Huang Songtao Qi Yaomin Li 
supported by the National Natural Science Foundation of China(No.82203368);Science and Technology Projects in Guangzhou,Guangdong,China(No.202201011008);College Students'Innovative Entrepreneurial Training Plan Program,China(No.202112121201).
Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 months.GBM heterogeneity is considered responsible for the treatment resistance and...
关键词：AUTOCRINE GLIOBLASTOMA Ligand-receptor interaction MICROENVIRONMENT PARACRINE Proneural-mesenchymal transition 
Effects of microenvironment and biological behavior on the paracrine function of stem cells被引量：2
《Genes & Diseases》2024年第1期135-147,共13页Zhixin Xue Yunjun Liao Ye Li 
supported by the Natural Science Foundation of Guangdong Province of China(No.2021A1515011623);the Administrator Foundation of Nanfang Hospital(China)(No.2019B021,2020z004);the National Nature Science Foundation of China(No.81971852).
Mesenchymal stem cells(MSCs),the most well-studied cell type in the field of stem cell therapy,have multi-lineage differentiation and self-renewal potential.MsC-based thera-pies have been used to treat diverse disease...
关键词：Bioactive behavior Mesenchymal stem cells MICROENVIRONMENT PARACRINE SECRETOME 
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog被引量：6
《Acta Pharmacologica Sinica》2023年第12期2404-2417,共14页Mei-jie Dai Xing-xing Gui Shu-miao Jia Shu-ting Lv Hao Dou Wei Cui 
the key program of the Educational Department of Liao Ning Province(Nos.LJKZZ20220100).
Dl-3-n-butylphthalide(NBP)is a small-molecule drug used in the treatment of ischemic stroke in China,which is proven to ameliorate the symptoms of ischemic stroke and improve the prognosis of patients.Previous studies...
关键词：ischemic stroke ANGIOGENESIS Dl-3-n-butylphthalide brain ischemia/reperfusion tMCAO model hedgehog signaling pathway 
Heparinized PGA host-guest hydrogel loaded with paracrine products from electrically stimulated adipose-derived mesenchymal stem cells for enhanced wound repair
《Engineered Regeneration》2023年第3期225-237,共13页Mengyao Li Junliang Li Xueru Xiong Yushi Wang Yong-Guang Jia Xuetao Shi Xiaoling Fu 
supported by the National Natu-ral Science Foundation of China (T2288101,31971266,82272152,22075087);Guangdong Basic and Applied Basic Research Foundation (2022A1515011925);the Key Research and Development Program of Guangzhou (202007020002).
The microenvironment of the wound bed is essential in the regulation of wound repair.In this regard,strategies that provide a repairing favorable microenvironment may effectively improve healing outcomes.Herein,we att...
关键词：Wound repair Electrical stimulation Paracrine factors Heparinized PGA host-guest hydrogel 
3D micropattern force triggers YAP nuclear entry by transport across nuclear pores and modulates stem cells paracrine被引量：4
《National Science Review》2023年第8期174-187,共14页Yan Li Zhenyu Zhong Cunjing Xu Xiaodan Wu Jiaqi Li Weiyong Tao Jianglin Wang Yingying Du Shengmin Zhang 
This work was supported by the National Natural Science Foundation of China(31430029,82130061 and 32171331);the Young Elite Scientist Sponsorship Program byChina Association for Science and Technology(YESS20200077);the Natural Science Foundation of Hubei Province(2021CFB609).
Biophysical cues of the cellular microenvironment tremendously influence cell behavior by mechanotransduction.However,it is still unclear how cells sense and transduce the mechanical signals from 3D geometry to regula...
关键词：bioactive materials tissue regeneration 3D micropattern force PARACRINE MECHANOTRANSDUCTION 
Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult被引量：6
《Science China(Life Sciences)》2023年第5期1067-1078,共12页Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong 
supported by the National Key R&D Program of China (2021YFF0501401);the National Natural Science Foundation of China (82030072);the Michigan Medicine-PKUHSC Joint Institute for Translational and Clinical Research (BMU2019JI007);the Fundamental Research Funds for the Central Universities;the National Natural Science Foundation of China (81830009, 81822003);the Beijing Municipal Natural Science Foundation (7191013);the Key Clinical Projects of Peking University Third Hospital (BYSYZD2019022);CAMS Innovation Fund for Medical Sciences to (2021-I2M-5-003)。
Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been ...
关键词：GALECTIN-3 interleukin-18 β-adrenergic receptor macrophage INFLAMMATION FIBROSIS 
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