Effects of microenvironment and biological behavior on the paracrine function of stem cells  

作　　者：Zhixin Xue Yunjun Liao Ye Li 

机构地区：[1]The Department of Plastic and Cosmetic Surgery,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China

出　　处：《Genes & Diseases》2024年第1期135-147,共13页基因与疾病（英文）

基　　金：supported by the Natural Science Foundation of Guangdong Province of China(No.2021A1515011623);the Administrator Foundation of Nanfang Hospital(China)(No.2019B021,2020z004);the National Nature Science Foundation of China(No.81971852).

摘　　要：Mesenchymal stem cells(MSCs),the most well-studied cell type in the field of stem cell therapy,have multi-lineage differentiation and self-renewal potential.MsC-based thera-pies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function.An increasing body of evidence demonstrates that paracrine func-tion is central to the effects of MsC-based therapy.Growth factors,cytokines,chemokines,extracellular matrix components,and extracellular vehicles all contribute to the beneficial ef-fects of MSCs on tissue regeneration and repair.The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior.In this review,we discuss the bioactive substances secreted by MsCs depending on the microenvironment and biological behavior and their regulatory mechanisms,which explain their potential to treat human diseases,to provide new ideas for further research and clinical cell-free therapy.

关 键 词：Bioactive behavior Mesenchymal stem cells MICROENVIRONMENT PARACRINE SECRETOME 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]