Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions  

作　　者：Yancheng Lai Xiaole Lu Yankai Liao Pei Ouyang Hai Wang Xian Zhang Guanglong Huang Songtao Qi Yaomin Li 

机构地区：[1]Department of Neurosurgery,Institute of Brain Disease,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China [2]Laboratory for Precision Neurosurgery,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515,China

出　　处：《Genes & Diseases》2024年第2期874-889,共16页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82203368);Science and Technology Projects in Guangzhou,Guangdong,China(No.202201011008);College Students'Innovative Entrepreneurial Training Plan Program,China(No.202112121201).

摘　　要：Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 months.GBM heterogeneity is considered responsible for the treatment resistance and unfavorable prognosis.Proneural-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment resistance.PMT is a complicated process influenced by crosstalk between GBM and tumor microenvironment,depending on intricate ligand-receptor interactions.In this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing PMT.We also discuss the current therapies targeting the PMT-related autocrine and paracrine pathways.Together,this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关 键 词：AUTOCRINE GLIOBLASTOMA Ligand-receptor interaction MICROENVIRONMENT PARACRINE Proneural-mesenchymal transition 

分 类 号：R739.4[医药卫生—肿瘤]