The secretory function of adipose tissues in metabolic regulation  

作　　者：Yang Liu Shu-Wen Qian Yan Tang Qi-Qun Tang 

机构地区：[1]Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education,Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital,Fudan University,Shanghai 200032,China

出　　处：《Life Metabolism》2024年第2期9-23,共15页生命代谢（英文）

基　　金：supported by the National Key R&D Program of China(grant 2018YFA0800400 to Q.Q.T.);the National Natural Science Foundation of China(NSFC)(grants 82370881,82170884,and 81970744 to Y.L.);Shanghai Rising-Star Program(grant 22QA1402100 to Y.L.).

摘　　要：In addition to their pivotal roles in energy storage and expenditure,adipose tissues play a crucial part in the secretion of bioactive molecules,including peptides,lipids,metabolites,and extracellular vesicles,in response to physiological stimulation and met-abolic stress.These secretory factors,through autocrine and paracrine mechanisms,regulate various processes within adipose tissues.These processes include adipogenesis,glucose and lipid metabolism,inflammation,and adaptive thermogenesis,all of which are essential for the maintenance of the balance and functionality of the adipose tissue micro-environment.A subset of these adipose-derived secretory factors can enter the circulation and target the distant tissues to regulate appetite,cognitive function,energy expenditure,insulin secretion and sensitivity,gluconeogenesis,cardiovascular remodeling,and exercise capac-ity.In this review,we highlight the role of adipose-derived secretory factors and their signaling pathways in modulating meta-bolic homeostasis.Furthermore,we delve into the alterations in both the content and secretion processes of these factors under various physiological and pathological conditions,shedding light on potential pharmacological treatment strategies for related diseases.

关 键 词：ADIPOKINES AUTOCRINE PARACRINE ENDOCRINE metabolic regulation 

分 类 号：Q493.5[生物学—生理学]