Small RNAs:Emerging key players in DNA double-strand break repair  

作　　者：BA ZhaoQing QI YiJun 

机构地区：[1]Tsinghua-Peking Center for Life Sciences,Center for Plant Biology,School of Life Sciences,Tsinghua University

出　　处：《Science China(Life Sciences)》2013年第10期933-936,共4页中国科学（生命科学英文版）

基　　金：supported in part by China National Funds for Distinguished Young Scientists(31225015);National Key Scientific Research Program of China(2012CB910900)to Qi YiJun

摘　　要：DNA double-strand break （DSB） is the most deleterious form of DNA damage and poses great threat to genome stability. Eu- karyotes have evolved complex mechanisms to repair DSBs through coordinated actions of protein sensors, transducers, and effectors. DSB-induced small RNAs （diRNAs） or Dicer/Drosha-dependent RNAs （DDRNAs） have been recently discovered in plants and vertebrates, adding an unsuspected RNA component into the DSB repair pathway. DiRNAs/DDRNAs control DNA damage response （DDR） activation by affecting DDR loci formation and cell cycle checkpoint enforcement and are required for efficient DSB repair. Here, we summarize the findings of diRNAs/DDRNAs and discuss the possible mechanisms through which they act to facilitate DSB repair.DNA double-strand break(DSB)is the most deleterious form of DNA damage and poses great threat to genome stability.Eukaryotes have evolved complex mechanisms to repair DSBs through coordinated actions of protein sensors,transducers,and effectors.DSB-induced small RNAs(diRNAs)or Dicer/Drosha-dependent RNAs(DDRNAs)have been recently discovered in plants and vertebrates,adding an unsuspected RNA component into the DSB repair pathway.DiRNAs/DDRNAs control DNA damage response(DDR)activation by affecting DDR foci formation and cell cycle checkpoint enforcement and are required for efficient DSB repair.Here,we summarize the findings of diRNAs/DDRNAs and discuss the possible mechanisms through which they act to facilitate DSB repair.

关 键 词：DNA damage small RNAs diRNA DICER ARGONAUTE 

分 类 号：Q522[生物学—生物化学]