糖尿病患者罹患结直肠癌风险的Meta分析  

Relationship between Diabetes Mellitus and Risk of Colorectal Cancer:A META-ANALYSIS

作　　者：曹宇华[1] 冯国生[1] 陈可和[1] 邱想英[1] 

机构地区：[1]广西壮族自治区人民医院临床肿瘤中心化疗科,南宁530021

出　　处：《结直肠肛门外科》2013年第3期164-167,共4页Journal of Colorectal & Anal Surgery

摘　　要：目的从循证医学角度探讨糖尿病(diabetes mellitus,DM)与结直肠癌(colorectal cancer,CRC)发生率的关系,明确糖尿病是否是促进结直肠癌发生的危险因素。方法应用meta分析的方法比较结直肠癌患者糖尿病病例数与对照组(非肿瘤患者)糖尿病的病例数,采用Revman 5.0统计学软件,以比值比(OR)为效应量进行合并分析。结果共纳入11个研究,211815例研究对象,meta分析结果显示:糖尿病患者结直肠癌的发生率较对照组高,差异有统计学意义[OR=I.80,95%CI(1.64,1.98)]。合并效应检验z=12.44,P<0.01。结论结肠癌的发病与糖尿病有一定相关性,糖尿病是促进结直肠癌发生的危险因素之一。Objective To investigate the relationship between Diabetes MelIitus（DM} and Coloreetal Canc- er{CRC） by the way of evidence-based medicine. Methods 11 randomized control studies of the numbers of DM patients in colorectal cancer patients group and in controls group {patients without cancer} were took into meta-analysis, Revman5.0 software was used for statistic alanalys. Results The results of meta-analy- ses of 11 cohort studies involving 211815 participants indicated that the diabetes patients had a higher inci- dence rate of colorectal cancer compared with the control group. The total effect size{odds ratio, OR} of 11 studies was 1.80,95% confidence interval （95%CI） was （1.64,1.98）, Z=12.44, P 〈0. 01. Conclusion DM have relationship with CRC,DM is one of the important pathogenic risk factors for colorectal cancer.

关 键 词：结直肠癌 结肠癌 直肠癌 糖尿病 META分析 

分 类 号：R735.3[医药卫生—肿瘤]