VEGFR-3、LYVE-1与直肠癌组织中表达及淋巴转移相关性的研究  

The relationship between lymphatic microvessel density and tumor metastasis by the expression of VEGFR-3 and LYVE-1 in rectal carcinoma

作　　者：陶成诚[1] 余昌俊[1] 孟刚[2] 曹志国[1] 陈昌裕[1] 龙腾云[1] 王岳君[2] 

机构地区：[1]安徽医科大学第一附属医院普通外科,合肥230022 [2]安徽医科大学第一附属医院病理诊断中心,合肥230022

出　　处：《安徽医科大学学报》2013年第10期1237-1239,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的通过研究血管内皮生长因子受体-3(VEGFR-3)、淋巴管内皮透明质酸受体-1(LYVE-1)在直肠癌组织、正常直肠组织淋巴管中的表达,分析直肠癌组织中微淋巴管密度(LMVD)与直肠癌淋巴结转移之间的关系。方法收集46例直肠癌石蜡切片和15例正常直肠组织,分析直肠癌组织及正常直肠组织中的淋巴管分布以及LMVD与直肠癌淋巴结转移、浸润之间的关系。结果直肠癌组织周围原有淋巴管增生、变异,新生功能性淋巴管明显增多,直肠癌组织LMVD与淋巴结转移、肿瘤大小和肿瘤浸润深度有关(P<0.05),与生物学特性和肿瘤部位无关。结论 VEGFR-3、LYVE-1在直肠癌组织淋巴管中的表达,促进了直肠癌的浸润及淋巴结转移。通过对针对VEGFR-3、LYVE-1的靶向治疗,可减少直肠癌的远处转移,检测VEGFR-3、LYVE-1可作为直肠癌治疗的预后指标。Objective To investigate the expressions of vascular endothelial growth factor receptor-3 （ VEGFR-3 ） and lymphatic vessel endothelial hyaluronan receptor-1 （ LYVE-1 ） in lymphatic vessel of rectal cancer tissue as well as normal rectal tissue to analyze the relationship between lymphatic microvessel density （LMVD） in rectal cancer tissue and lymphatic metastasis, and discuss the new targets for rectal cancer therapy. Methods 46 paraffin-embedded rectal cancer tissue specimens and 15 normal rectal tissue specimens were collected from department of pathology in the first affiliated hospital of Anhui Medical University to study the relationship between the distribu- tion of lymphatic vessel, lymphatic microvessel density in normal rectal tissue as well as rectal cancer tissue and rectal cancer lymphatic metastasis as well as infiltration. Results Obvious increasing of lymphatic hyperplasia, variation and functional lymphangiogenesis showed around rectal cancer tissue. LMVD of rectal cancer tissue was related to lymphatic metastasis, tumor size and serosa-infihrating （ P 〈 0. 05 ）, but was not related to biological characteristics and tumor position. Conclusion The expressions of VEGFR-3 and LYVE-1 in rectal cancer tissue enhance rectal cancer infiltration and lymphatic metastasis. Targeted therapy of VEGFR-3 and LYVE-1 can reduce rectal cancer distant metastasis. Tests on VEGFR-3 and LYVE-1 can be used as prognostic indicator of treatments for rectal cancer.

关 键 词：直肠癌 微淋巴管密度 VEGFR-3 LYVE-1 淋巴结 转移 

分 类 号：R73-37[医药卫生—肿瘤]