血清脑源性神经营养因子水平与血管性痴呆的相关性研究  

Correlation study of serum brain-derived neurotrophic factor with vascular dementia

作　　者：冯学敏[1] 刘晓冰[2] 张仁生[1] 周春奎[1] 

机构地区：[1]吉林大学白求恩第一医院神经内科,吉林长春130021 [2]国土资源航空物探遥感中心卫生所,北京100083

出　　处：《中风与神经疾病杂志》2013年第9期821-823,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨血清脑源性神经营养因子水平(BDNF)与血管性痴呆(VD)的相关性。方法选择32例VD患者、35例脑梗死患者和35例正常健康对照者,利用酶联免疫吸附法测定外周血清BDNF水平。并对所有观察对象一般临床资料进行比较,寻找VD的危险因素。结果高血压病在3组中相比,均有显著差异(P<0.05);3组血清中BDNF浓度在脑梗死组最高,VD组最低,VD组与脑梗死组有显著性差异、与健康对照组相比无显著性差异。脑梗死组与正常组相比无显著性差异。结论脑梗死患者血清BDNF浓度稍高于与健康对照者,但无明显差异。VD患者血清BDNF水平明显低于脑梗死患者,且具有显著性差异,但与正常组相比无明显差异。提示BDNF可能参与了脑梗死进展为VD的病理生理过程。Objective To explore the association between the serum level of brain derived neurotrophic factor （ BD- NF） and vascular dementia （VD）. Methods 32 patients of VD,35 cerebral infarct patients were selected. 35 health ex- aminated people were chosen simultaneously as controls, in. Enzyme-linked immunosorbant assay （ELISA） was used to measure the serum levels of BDNF. Analyze clinical data to search risk factors to vascular dementia. Results Hyperten- sion showed significantly difference among the three groups （ P 〈 0.05 ）. Serum BNDF concentration of three groups in non- demented cerebral infarction group was the highest, while lowest in vascular dementia group, we found that there are signifi- cantly difference between VD and CI, but nosignificantly difference between VD and normal control. Conclusion Serum BDNF level of cerebral infarction patients were slightly above normal controls, but no obvious difference was found. VD pa- tients serum levels of BDNF significantly below the CI, and has the significant difference, there was no obvious difference compared with the normal group, BDNF may be involved in the cerebral infarction progress for vascular dementia pathophys- iological events.

关 键 词：血管性痴呆 脑源性神经营养因子 

分 类 号：R749.13[医药卫生—神经病学与精神病学]