疫苗干粉吸入剂的研究进展  

Development of Vaccine Dry Powders for Inhalation

作　　者：姜俊峰[1] 安悦[1] 徐恩宇[1] 郭静[2] 李浩莹[2] 

机构地区：[1]辽宁师范大学化学化工学院,辽宁大连116029 [2]苏州大学生物制造研究中心,江苏苏州215021

出　　处：《河北师范大学学报（自然科学版）》2013年第5期536-540,共5页Journal of Hebei Normal University：Natural Science

基　　金：江苏省自然科学基金(BK2011295)

摘　　要：疫苗干粉吸入剂的肺部有效沉积率及其稳定性是衡量药物可靠性的重要标准.主要介绍了相关疫苗干粉制剂的制备工艺及辅料对其疫苗干粉颗粒的物理特性包括粒径大小及分布、表面形貌、分散性、流动性、密度、水分含量以及药理活性的影响.The fine particle fraction and stability are the key factors to formulate vaccine dry powders for inhalation. In this review, we summarized the approaches to manufacture vaccine dry powders for inhalation. Additionally, the influence of excipients on the physiochemical properties of vaccine dry powders were described and discussed, including the particle size distribution, surface morphology, dispersibility, mobility,density,moisture content and biological activities of vaccine in the dry powders.

关 键 词：疫苗 稳定剂辅料 干粉吸入剂 喷雾干燥 

分 类 号：R944.27[医药卫生—药剂学] TQ423[医药卫生—药学]