FGF10基因rs399501位点与中国汉族人群高度近视相关性  

THE ASSOCIATION OF RS399501AT FGF10GENE WITH HIGH MYOPIA IN CHINESE HAN POPULATION

作　　者：杨先[1] 赵桂秋[1] 管洪在[2] 孟岩[1] 宁美真 孔庆兰[1] 

机构地区：[1]青岛大学医学院附属医院眼科,山东青岛266003 [2]青岛大学医学院血液病学教研室 [3]青岛市第九人民医院眼科

出　　处：《青岛大学医学院学报》2013年第6期500-502,505,共4页Acta Academiae Medicinae Qingdao Universitatis

基　　金：山东省博士基金(BS2010SF009)

摘　　要：目的探讨FGF10基因rs399501位点与中国汉族人群高度近视的相关性。方法选择442例高度近视病人和551例视力正常的健康者(均为中国汉族)作为研究对象,应用单碱基延伸法(SNaPshot技术)对其rs399501位点进行基因分型,分析rs399501位点基因型及等位基因频率与高度近视的关系。结果高度近视组和对照组基因型均符合Hardy-Weinberg平衡(P>0.05)。FGF10基因rs399501位点基因型GG、等位基因G与中国汉族人群高度近视高度相关(OR=3.05、1.35,P<0.05)。结论 FGF10基因可能参与了高度近视发生发展。Objective To study the association between rs399501 at FGF10 gene and high myopia in Chinese Han popu- lation. Methods This study enrolll／ed 442 patients with high myopia and 551 healthy controls from Chinese Han population. SNP rs399501 at FGF10 gene was genotyped by SNaPshot technique. Chi square test was performed to determine the association be tween genotypes and alleles of SNP rs339501 and the susceptibility of high myopia. Results All the genotype frequencies were in Hardy-Weinberg equilibrium （P〉0.05）. The risk allele G and genotype GG of SNP rs339501 at FGF10 gene were significantly as- sociated with high myopia （OR = 3.05,1.35 ,P〈0.05）. Conclusion FGF10 gene is likely involved in the occurrence and develop ment of excessive myopia.

关 键 词：近视 成纤维细胞生长因子10 多态性 单核苷酸 

分 类 号：R778.1[医药卫生—眼科] R394.3[医药卫生—临床医学]